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The major efferent target of the ventromedial hypothalamus is the dorsal periaqueductal grey, and stimulation of this structure also elicits flight, freezing, and sympathetic activation. However, reversible inhibition experiments suggest that the ventromedial hypothalamus and periaqueductal grey play distinct roles in the control of defensive behavior, with the former proposed to encode an internal state necessary for the motivation of defensive responses, while the latter serves as a motor pattern initiator. Here we used electrophysiological recordings of single units in behaving mice exposed to a rat to investigate the encoding of predator fear in the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey. Distinct correlates of threat intensity and motor responses were found in both structures, suggesting a distributed encoding of sensory and motor features in the medial hypothalamic-brainstem instinctive network.<\/jats:p>","DOI":"10.1101\/283820","type":"posted-content","created":{"date-parts":[[2018,3,17]],"date-time":"2018-03-17T15:00:13Z","timestamp":1521298813000},"source":"Crossref","is-referenced-by-count":4,"title":["Differential encoding of predator fear in the ventromedial hypothalamus and periaqueductal grey"],"prefix":"10.64898","author":[{"given":"Maria Esteban","family":"Masferrer","sequence":"first","affiliation":[]},{"given":"Bianca A.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Kensaku","family":"Nomoto","sequence":"additional","affiliation":[]},{"given":"Susana Q.","family":"Lima","sequence":"additional","affiliation":[]},{"given":"Cornelius T.","family":"Gross","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"key":"2019072214450749000_283820v1.1","first-page":"123","article-title":"Endorphins and pain relief. 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