{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:50:37Z","timestamp":1768477837623,"version":"3.49.0"},"posted":{"date-parts":[[2018,5,30]]},"group-title":"Neuroscience","reference-count":120,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2018,5,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Weber\u2019s law states that the discriminability between two stimulus intensities depends only on their ratio. Despite its status as the cornerstone of psychophysics, the mecha-nisms underlying Weber\u2019s law are still debated, as no principled way exists to choose between its many proposed alternative explanations. We studied this problem training rats to discriminate the lateralization of sounds of different overall level. We found that the rats\u2019 discrimination accuracy in this task is level-invariant, consistent with Weber\u2019s law. Surprisingly, the shape of the reaction time distributions is also level-invariant, implying that the only behavioral effect of changes in the overall level of the sounds is a uniform scaling of time. Furthermore, we demonstrate that Weber\u2019s law breaks down if the stimulus duration is capped at values shorter than the typical reaction time. Together, these facts suggest that Weber\u2019s law is associated to a process of bounded evidence accumulation. Consistent with this hypothesis, we show that, among a broad class of sequential sampling models, the only robust mechanism consistent with reaction time scale-invariance is based on perfect accumulation of evidence up to a constant bound, Poisson-like statistics, and a power-law encoding of stimulus intensity. Fits of a minimal diffusion model with these characteristics describe the rats performance and reaction time distributions with virtually no error. Various manipulations of motivation were unable to alter the rats\u2019 psychometric function, demonstrating the stability of the just-noticeable-difference and suggesting that, at least under some conditions, the bound for evidence accumulation can set a hard limit on discrimination accuracy. Our results establish the mechanistic foundation of the process of intensity discrimination and clarify the factors that limit the precision of sensory systems.<\/jats:p>","DOI":"10.1101\/333559","type":"posted-content","created":{"date-parts":[[2018,5,30]],"date-time":"2018-05-30T18:10:12Z","timestamp":1527703812000},"source":"Crossref","is-referenced-by-count":4,"title":["Weber\u2019s law is the result of exact temporal accumulation of evidence"],"prefix":"10.64898","author":[{"given":"Jose L.","family":"Pardo-Vazquez","sequence":"first","affiliation":[]},{"given":"Juan","family":"Casti\u00f1eiras","sequence":"additional","affiliation":[]},{"given":"Mafalda","family":"Valente","sequence":"additional","affiliation":[]},{"given":"Tiago","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Alfonso","family":"Renart","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"key":"2019071911513070000_333559v1.1","unstructured":"E. H. 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