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Using a novel transgenic steroidogenesis-reporter mouse line we identify and characterize\n                  <jats:italic>de novo<\/jats:italic>\n                  steroidogenic immune cells. Genetic ablation of T cell steroidogenesis restricts primary tumor growth and metastatic dissemination in mouse models. Steroidogenic T cells dysregulate anti-tumor immunity, and inhibition of the steroidogenesis pathway was sufficient to restore anti-tumor immunity. This study demonstrates T cell\n                  <jats:italic>de novo<\/jats:italic>\n                  steroidogenesis as a mechanism of anti-tumor immunosuppression and a potential druggable target.\n                <\/jats:p>","DOI":"10.1101\/471359","type":"posted-content","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T05:56:47Z","timestamp":1542607007000},"source":"Crossref","is-referenced-by-count":1,"title":["Tumors induce\n                  <i>de novo<\/i>\n                  steroid biosynthesis in T cells to evade immunity"],"prefix":"10.64898","author":[{"given":"Bidesh","family":"Mahata","sequence":"first","affiliation":[]},{"given":"Jhuma","family":"Pramanik","sequence":"additional","affiliation":[]},{"given":"Louise","family":"van der 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