{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:10:46Z","timestamp":1768475446393,"version":"3.49.0"},"posted":{"date-parts":[[2019,3,9]]},"group-title":"Pathology","reference-count":19,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2019,3,9]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n \n The Hypoxia Altitude Simulation Test (HAST) is the\n Gold Standard<\/jats:italic>\n to evaluate hypoxia in response to altitude and to decide on in-flight requirements for oxygen supplementation. Several equations are available to predict PaO\n 2<\/jats:sub>\n in altitude (PaO\n 2alt<\/jats:sub>\n ), but it remains unclear whether their predictive value is equivalent. We aimed to compare the results obtained by the available methods in a population of cystic fibrosis (CF) adults.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Eighty-eight adults (58 healthy controls and 30 CF patients) performed a spirometry followed by an HAST. HAST results were compared with the predicted PaO\n 2alt<\/jats:sub>\n made by five equations: 1\n st<\/jats:sup>\n : PaO\n 2alt<\/jats:sub>\n = 0,410 x PaO\n 2ground<\/jats:sub>\n + 1,7652; 2\n nd<\/jats:sup>\n : PaO\n 2alt<\/jats:sub>\n = 0,519 x PaO\n 2ground<\/jats:sub>\n + 11,855 x FEV\n 1<\/jats:sub>\n (L) \u2212 1,760; 3\n rd<\/jats:sup>\n : PaO\n 2alt<\/jats:sub>\n = 0,453 x PaO\n 2ground<\/jats:sub>\n + 0,386 x FEV\n 1<\/jats:sub>\n (%) + 2,44; 4\n th<\/jats:sup>\n : PaO\n 2alt<\/jats:sub>\n = 0,88 + 0,68 x PaO\n 2ground<\/jats:sub>\n ; 5\n th<\/jats:sup>\n : PaO\n 2alt<\/jats:sub>\n = PaO\n 2ground<\/jats:sub>\n \u2212 26,6.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n None of the controls required in-flight oxygen neither by HAST or by the five predictive equations. Eleven CF-patients had PaO\n 2alt<\/jats:sub>\n < 50 mmHg, accessed by HAST. The positive predictive value was 50% (1\n st<\/jats:sup>\n ), 87.5% (2\n nd<\/jats:sup>\n and 3\n rd<\/jats:sup>\n ), 77.78% (4\n th<\/jats:sup>\n ) and 58.33% (5\n th<\/jats:sup>\n ). Areas under the curve were 78.95% (1\n st<\/jats:sup>\n ), 84.69% (2\n nd<\/jats:sup>\n ), 88.04% (3\n rd<\/jats:sup>\n ) and 78.95% (4\n th<\/jats:sup>\n and 5\n th<\/jats:sup>\n ). FEV\n 1<\/jats:sub>\n and PaO\n 2ground<\/jats:sub>\n were correlated with HAST results.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The 3rd equation gave the best predictions in comparison with results obtained by HAST. However, because the individual differences found were substantial for all equations, we still recommend performing a HAST whenever possible to confidently access in-flight hypoxia and the need for oxygen.<\/jats:p>\n <\/jats:sec>","DOI":"10.1101\/570754","type":"posted-content","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T16:25:14Z","timestamp":1552148714000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison Between Normobaric Hypoxia Altitude Simulation Test and Altitude Hypoxia Predictive Equations in Cystic Fibrosis Patients"],"prefix":"10.64898","author":[{"given":"Christine","family":"Costa","sequence":"first","affiliation":[]},{"given":"Andr\u00e9","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Valen\u00e7a","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Richard","family":"Staats","sequence":"additional","affiliation":[]},{"given":"Mariana","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Pilar","family":"Cardim","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Barbara","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0707-315X","authenticated-orcid":false,"given":"Lu\u00eds F.","family":"Moita","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Moreira","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"issue":"1","key":"2019031414251106000_570754v1.1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13104-017-2386-2","article-title":"Pre-flight evaluation of adult patients with cystic fibrosis: a cross-sectional study","volume":"10","year":"2017","journal-title":"BMC research notes."},{"issue":"6","key":"2019031414251106000_570754v1.2","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jcf.2010.08.013","article-title":"Department of Pulmonary Medicine GCfDWG, Bradley J, et al. 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