{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T12:57:28Z","timestamp":1768481848462,"version":"3.49.0"},"posted":{"date-parts":[[2019,5,31]]},"group-title":"Epidemiology","reference-count":27,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2019,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>The State of Rio de Janeiro stands out as having the second highest incidence and the highest mortality rate due to TB in Brazil. This study aims at identifying the factors associated with the unfavourable treatment of MDR\/XDR-TB patients in that State.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Data on 2269 MDR-TB cases reported in 2000-2016 in Rio de Janeiro State were collected from the Tuberculosis Surveillance System. Bivariate and multivariate logistic regressions were run to estimate the factors associated with unfavourable outcomes (failure, default, and death) and, specifically, default and death.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The proportion of unfavourable outcomes was 41.9% among MDR-TB and 81.5% among XDR-TB. Having less than 8 years of schooling, and being an Afro-Brazilian, under 40 years old and drug user were associated with unfavourable outcome and default. Bilateral disease, HIV positive, and comorbidities were associated with death. XDR-TB cases had a 4.7-fold higher odds of an unfavourable outcome, with 29.3% of such cases being in the first treatment for multidrug resistance.<\/jats:p>\n                <\/jats:sec>\n                <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>About 30% of XDR-TB cases may have occurred by primary transmission. The high rates of failure and death in this category reflect the limitation of treatment options. This highlights the urgency to incorporate new drugs in the treatment.<\/jats:p>\n                <\/jats:sec>","DOI":"10.1101\/656884","type":"posted-content","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T19:55:13Z","timestamp":1559332513000},"source":"Crossref","is-referenced-by-count":3,"title":["Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1568-026X","authenticated-orcid":false,"given":"Marcela","family":"Bhering","sequence":"first","affiliation":[]},{"given":"Raquel","family":"Duarte","sequence":"additional","affiliation":[]},{"given":"Afr\u00e2nio","family":"Kritski","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"key":"2019060210550451000_656884v1.1","unstructured":"World Health Organization (WHO). Global Tuberculosis Report 2018. Geneva:WHO. 2018."},{"issue":"7","key":"2019060210550451000_656884v1.2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMp068273","article-title":"XDR Tuberculosis \u2014 Implications for Global Public Health","volume":"356","year":"2007","journal-title":"N Engl J Med [Internet]"},{"key":"2019060210550451000_656884v1.3","first-page":"18","article-title":"Implanta\u00e7\u00e3o do Plano Nacional pelo Fim da Tuberculose como Problema de Sa\u00fade P\u00fablica no Brasil: primeiros passos rumo ao alcance das metas","volume":"49","year":"2018","journal-title":"Bol Epidemiol"},{"key":"2019060210550451000_656884v1.4","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (IBGE). Pesquisa nacional por amostra de domic\u00edlios (PNAD) 2015. https:\/\/www.ibge.gov.br\/estatisticas-novoportal\/sociais\/rendimento-despesa-e-consumo\/9127-pesquisa-nacional-por-amostra-de-domicilios.html?=&t=series-historicas."},{"key":"2019060210550451000_656884v1.5","first-page":"1","article-title":"Descentraliza\u00e7\u00e3o do Acesso ao Sistema de Informa\u00e7\u00f5es de tratamentos especiais em tuberculose","volume":"32","year":"2018","journal-title":"Rev Baiana Enfermagem"},{"issue":"6","key":"2019060210550451000_656884v1.6","first-page":"640","article-title":"Speaking the same language: Treatment outcome definitions for multidrug-resistant tuberculosis","volume":"9","year":"2005","journal-title":"Int J Tuberc Lung Dis"},{"key":"2019060210550451000_656884v1.7","unstructured":"World Health Organization (WHO). Anti-tuberculosis drug resistance in the world: third global report\/ The WHO\/IUATLD Global Project on Anti-Tuberculosis Drug Resistance Surveillance, 1999-2002.. Geneva:WHO. 2004."},{"key":"2019060210550451000_656884v1.8","unstructured":"Departamento de Vigil\u00e2ncia Epidemiol\u00f3gica, Secretaria de Vigil\u00e2ncia em Sa\u00fade, Minist\u00e9rio da Sa\u00fade. Manual de recomenda\u00e7\u00f5es para o controle da tuberculose no Brasil. Bras\u00edlia: Minist\u00e9rio da Sa\u00fade, 2011."},{"issue":"3","key":"2019060210550451000_656884v1.9","doi-asserted-by":"crossref","first-page":"pii:1600803","DOI":"10.1183\/13993003.00803-2016","article-title":"An updated systematic review and metaanalysis for treatment of multidrug-resistant tuberculosis","volume":"49","year":"2017","journal-title":"Eur Respir J"},{"issue":"1","key":"2019060210550451000_656884v1.10","first-page":"1","article-title":"Treatment outcomes of MDR-tuberculosis patients in Brazil: A retrospective cohort analysis","volume":"17","year":"2017","journal-title":"BMC Infect Dis"},{"issue":"49","key":"2019060210550451000_656884v1.11","first-page":"1","article-title":"Tuberculosis treatment outcome in the European Union and European Economic Area: an analysis of surveillance data from 2002-2011","volume":"20","year":"2015","journal-title":"Euro Surveill"},{"key":"2019060210550451000_656884v1.12","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-89102007000800006"},{"key":"2019060210550451000_656884v1.13","doi-asserted-by":"crossref","unstructured":"Paula HC de , Aguiar AC de . O abandono do tratamento da tuberculose na estrat\u00e9gia sa\u00fade da fam\u00edlia: estudo qualitativo em uma \u00e1rea program\u00e1tica do Rio de Janeiro. Rev Baiana Saude Publica. 2013;192\u2013204.","DOI":"10.22278\/2318-2660.2013.v37.n1.a356"},{"key":"2019060210550451000_656884v1.14","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00193413"},{"key":"2019060210550451000_656884v1.15","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00274-2018"},{"issue":"1","key":"2019060210550451000_656884v1.16","first-page":"1","article-title":"Effects of social protection on tuberculosis treatment outcomes in low or middle-income and in high-burden countries: systematic review and meta-analysis","volume":"34","year":"2018","journal-title":"Cad Saude Publica"},{"key":"2019060210550451000_656884v1.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010840"},{"issue":"1","key":"2019060210550451000_656884v1.18","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1038\/s41598-018-23344-z","article-title":"Comorbidities and treatment outcomes in multidrug resistant tuberculosis: a systematic review and meta-analysis","volume":"8","year":"2018","journal-title":"Sci Rep"},{"key":"2019060210550451000_656884v1.19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093574"},{"issue":"2","key":"2019060210550451000_656884v1.20","first-page":"145","article-title":"Fatores de risco para tuberculose?: diabetes, tabagismo, \u00e1lcool e uso de outras drogas","volume":"44","year":"2018","journal-title":"J Bras Pneum"},{"issue":"1","key":"2019060210550451000_656884v1.21","first-page":"1","article-title":"Predictors of unsuccessful interim treatment outcomes of multidrug resistant tuberculosis patients","volume":"17","year":"2017","journal-title":"BMC Infect Dis"},{"key":"2019060210550451000_656884v1.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2015.09.011"},{"key":"2019060210550451000_656884v1.23","first-page":"315","article-title":"Prescri\u00e7\u00e3o de antibacterianos em Cl\u00ednica Geral: Um estudo na Rede M\u00e9dicos-Sentinela","volume":"19","year":"2003","journal-title":"Rev Port Clin Geral"},{"key":"2019060210550451000_656884v1.24","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00134712"},{"issue":"9728","key":"2019060210550451000_656884v1.25","first-page":"1830","article-title":"Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis","volume":"375","year":"2010","journal-title":"Lancet Respir Med"},{"issue":"11","key":"2019060210550451000_656884v1.26","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.5588\/ijtld.10.0679","article-title":"Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan","volume":"15","year":"2011","journal-title":"Int J Tuberc Lung Dis"},{"issue":"3","key":"2019060210550451000_656884v1.27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S2213-2600(15)00036-3","article-title":"Sputum culture conversion as a prognostic marker for end-of-treatment outcome in patients with multidrug-resistant tuberculosis: a secondary analysis of data from two observational cohort studies","volume":"3","year":"2015","journal-title":"Lancet Respir Med"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1101\/656884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:13:55Z","timestamp":1768432435000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/656884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,31]]},"references-count":27,"URL":"https:\/\/doi.org\/10.1101\/656884","relation":{"is-preprint-of":[{"id-type":"doi","id":"10.1371\/journal.pone.0218299","asserted-by":"subject"}]},"subject":[],"published":{"date-parts":[[2019,5,31]]},"subtype":"preprint"}}