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Quantitative proteomics following sequential reprogramming revealed that autophagy is required for timely decay of previous cellular states and for tweaking the proteome to acclimate to the new conditions. Signatures of previous cellular programs thus persist in autophagy deficient cells, affecting cellular decision-making. Concordantly, autophagy deficient cells fail to acclimatize to dynamic climate changes. Similarly, they have defects in dedifferentiating into pluripotent stem cells, and redifferentiation during organogenesis. These observations indicate that autophagy mediates cell state switches that underlie somatic cell reprogramming in plants and possibly other organisms, and thereby promotes phenotypic plasticity.<\/jats:p>","DOI":"10.1101\/747410","type":"posted-content","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T23:05:12Z","timestamp":1567033512000},"source":"Crossref","is-referenced-by-count":0,"title":["Autophagy mediates temporary reprogramming and dedifferentiation in plant somatic cells"],"prefix":"10.64898","author":[{"given":"Eleazar","family":"Rodriguez","sequence":"first","affiliation":[]},{"given":"Jonathan","family":"Chevalier","sequence":"additional","affiliation":[]},{"given":"Jakob","family":"Olsen","sequence":"additional","affiliation":[]},{"given":"Jeppe","family":"Ansb\u00f8l","sequence":"additional","affiliation":[]},{"given":"Vaitsa","family":"Kapousidou","sequence":"additional","affiliation":[]},{"given":"Zhangli","family":"Zuo","sequence":"additional","affiliation":[]},{"given":"Steingrim","family":"Svenning","sequence":"additional","affiliation":[]},{"given":"Christian","family":"Loefke","sequence":"additional","affiliation":[]},{"given":"Stefanie","family":"Koemeda","sequence":"additional","affiliation":[]},{"given":"Pedro Serrano","family":"Drozdowskyj","sequence":"additional","affiliation":[]},{"given":"Jakub","family":"Jez","sequence":"additional","affiliation":[]},{"given":"Gerhard","family":"Durnberger","sequence":"additional","affiliation":[]},{"given":"Fabian","family":"Kuenzl","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Schutzbier","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3392-9946","authenticated-orcid":false,"given":"Karl","family":"Mechtler","sequence":"additional","affiliation":[]},{"given":"Signe","family":"Lolle","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9502-355X","authenticated-orcid":false,"given":"Yasin","family":"Dagdas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-5991","authenticated-orcid":false,"given":"Morten","family":"Petersen","sequence":"additional","affiliation":[]}],"member":"54368","reference":[{"key":"2019083003351448000_747410v1.1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.2092"},{"key":"2019083003351448000_747410v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.048"},{"key":"2019083003351448000_747410v1.3","first-page":"571","article-title":"Comparing variances and other measures of dispersion","volume":"19","year":"2005","journal-title":"Stat. 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