{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:50:37Z","timestamp":1768485037584,"version":"3.49.0"},"posted":{"date-parts":[[2019,10,29]]},"group-title":"Neuroscience","reference-count":87,"publisher":"openRxiv","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2019,10,29]]},"abstract":"<jats:p>\n                  The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved metabolomics to show that in\n                  <jats:italic>Drosophila melanogaster, Aceto-bacter pomorum<\/jats:italic>\n                  (\n                  <jats:italic>Ap<\/jats:italic>\n                  ) and\n                  <jats:italic>Lactobacillus plantarum<\/jats:italic>\n                  (\n                  <jats:italic>Lp<\/jats:italic>\n                  ) establish a syntrophic relationship to overcome detrimental host diets and identify\n                  <jats:italic>Ap<\/jats:italic>\n                  as the bacterium altering the host\u2019s feeding decisions. Specifically, we show that\n                  <jats:italic>Lp<\/jats:italic>\n                  generates lactate which is used by\n                  <jats:italic>Ap<\/jats:italic>\n                  to produce and provide amino acids that are essential to\n                  <jats:italic>Lp<\/jats:italic>\n                  allowing it to grow in imbalanced diets. Lactate is also necessary and sufficient for\n                  <jats:italic>Ap<\/jats:italic>\n                  to alter the fly\u2019s protein appetite. Our data show that gut bacterial communities use metabolic interactions to become resilient to detrimental host diets and to ensure the constant flow of metabolites used by effector bacteria to alter host behaviour.\n                <\/jats:p>","DOI":"10.1101\/821892","type":"posted-content","created":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T09:35:57Z","timestamp":1572341757000},"source":"Crossref","is-referenced-by-count":2,"title":["Metabolic cross-feeding allows a gut microbial community to overcome detrimental diets and alter host behaviour"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-1573","authenticated-orcid":false,"given":"S\u00edlvia F.","family":"Henriques","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4850-2934","authenticated-orcid":false,"given":"L\u00facia","family":"Serra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-2148","authenticated-orcid":false,"given":"Ana Patr\u00edcia","family":"Francisco","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-308X","authenticated-orcid":false,"given":"Zita","family":"Carvalho-Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-9749","authenticated-orcid":false,"given":"C\u00e9lia","family":"Baltazar","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1085-4814","authenticated-orcid":false,"given":"Ana Paula","family":"Elias","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-0209","authenticated-orcid":false,"given":"Margarida","family":"Anjos","sequence":"additional","affiliation":[]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5551-9091","authenticated-orcid":false,"given":"Oliver D. 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