{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:29:26Z","timestamp":1774632566878,"version":"3.50.1"},"reference-count":41,"publisher":"Cold Spring Harbor Laboratory","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:p>\n                    Mutation of the\n                    <jats:italic>Neurofibromatosis 2<\/jats:italic>\n                    (\n                    <jats:italic>NF2<\/jats:italic>\n                    ) tumor suppressor gene leads to cancer development in humans and mice. Recent studies suggest that\n                    <jats:italic>Nf2<\/jats:italic>\n                    loss also contributes to tumor metastasis. The\n                    <jats:italic>Nf2<\/jats:italic>\n                    -encoded protein, merlin, is related to the ERM (\n                    <jats:underline>e<\/jats:underline>\n                    zrin,\n                    <jats:underline>r<\/jats:underline>\n                    adixin, and\n                    <jats:underline>m<\/jats:underline>\n                    oesin) family of membrane:cytoskeleton-associated proteins. However, the cellular mechanism whereby merlin controls cell proliferation from this location is not known. Here we show that the major cellular consequence of\n                    <jats:italic>Nf2<\/jats:italic>\n                    deficiency in primary cells is an inability to undergo contact-dependent growth arrest and to form stable cadherin-containing cell:cell junctions. Merlin colocalizes and interacts with adherens junction (AJ) components in confluent wild-type cells, suggesting that the lack of AJs and contact-dependent growth arrest in\n                    <jats:italic>Nf2<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    cells directly results from the absence of merlin at sites of cell:cell contact. Our studies indicate that merlin functions as a tumor and metastasis suppressor by controlling cadherin-mediated cell:cell contact.\n                  <\/jats:p>","DOI":"10.1101\/gad.1054603","type":"journal-article","created":{"date-parts":[[2003,5,2]],"date-time":"2003-05-02T13:14:02Z","timestamp":1051881242000},"page":"1090-1100","source":"Crossref","is-referenced-by-count":258,"title":["<i>NF2<\/i>\n                    deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions"],"prefix":"10.1101","volume":"17","author":[{"given":"Dominique","family":"Lallemand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Curto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiko","family":"Saotome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Giovannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea I.","family":"McClatchey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[2003,4,14]]},"reference":[{"key":"2021111519023744000_17.9.1090.1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.4.1105"},{"key":"2021111519023744000_17.9.1090.2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.134.2.549"},{"key":"2021111519023744000_17.9.1090.3","doi-asserted-by":"publisher","DOI":"10.1038\/418823a"},{"key":"2021111519023744000_17.9.1090.4","doi-asserted-by":"publisher","DOI":"10.1038\/nrm882"},{"key":"2021111519023744000_17.9.1090.5","first-page":"39","article-title":"Cell adhesion in tumor invasion andmetastasis: Loss of the glue is not enough.","volume":"1552","author":"Cavallaro","year":"2001","journal-title":"Biochim. 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