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Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated promoter. Our data confirm that histone methylation does not occur randomly but rather is a targeted event and provides one mechanism by which HMTs can be recruited to chromatin to activate gene expression.<\/jats:p>","DOI":"10.1101\/gad.1068003","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T18:16:00Z","timestamp":1050603360000},"page":"1019-1029","source":"Crossref","is-referenced-by-count":153,"title":["Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1"],"prefix":"10.1101","volume":"17","author":[{"given":"Natalie","family":"Rezai-Zadeh","sequence":"first","affiliation":[]},{"given":"Xiaohong","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Fares","family":"Namour","sequence":"additional","affiliation":[]},{"given":"Gyorgy","family":"Fejer","sequence":"additional","affiliation":[]},{"given":"Yu-Der","family":"Wen","sequence":"additional","affiliation":[]},{"given":"Ya-Li","family":"Yao","sequence":"additional","affiliation":[]},{"given":"Ildiko","family":"Gyory","sequence":"additional","affiliation":[]},{"given":"Kenneth","family":"Wright","sequence":"additional","affiliation":[]},{"given":"Edward","family":"Seto","sequence":"additional","affiliation":[]}],"member":"246","published-online":{"date-parts":[[2003,4,15]]},"reference":[{"key":"2021111519023690000_17.8.1019.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204324"},{"key":"2021111519023690000_17.8.1019.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-437X(02)00279-4"},{"key":"2021111519023690000_17.8.1019.3","doi-asserted-by":"publisher","DOI":"10.1038\/35404"},{"key":"2021111519023690000_17.8.1019.4","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5423.2174"},{"key":"2021111519023690000_17.8.1019.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00118-5"},{"key":"2021111519023690000_17.8.1019.6","doi-asserted-by":"crossref","first-page":"20682","DOI":"10.1016\/S0021-9258(17)32047-1","article-title":"Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter.","volume":"269","author":"Corthesy","year":"1994","journal-title":"J. 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