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Furthermore, only a fraction of O-2A cells derived from p27-knockout mice differentiate successfully compared to controls. Inability to differentiate correlates with continued proliferation, suggesting that p27 is an important component of the machinery required for the G<jats:sub>1<\/jats:sub>\/G<jats:sub>0<\/jats:sub> transition in O-2A cells. In vivo, expansion of O-2A precursors before withdrawal, in part, leads to a greater number of oligodendrocytes. Together these data indicate a role for p27 during the decision to withdraw from the cell cycle in the oligodendrocyte lineage.<\/jats:p>","DOI":"10.1101\/gad.11.18.2335","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T22:15:26Z","timestamp":1203545726000},"page":"2335-2346","source":"Crossref","is-referenced-by-count":221,"title":["Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor\u2009p27<sup>Kip1<\/sup>"],"prefix":"10.1101","volume":"11","author":[{"given":"Patrizia","family":"Casaccia-Bonnefil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Tikoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Kiyokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Victor","family":"Friedrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses V.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Koff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1997,9,15]]},"reference":[{"key":"2021111418471956000_11.18.2335.1","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1128\/MCB.16.8.4327","article-title":"Repression of p27Kip1 synthesis by platelet-derived growth factor in Balb\/c 3T3 cells.","volume":"8","author":"Agrawal","year":"1996","journal-title":"Mol. 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