{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:30:31Z","timestamp":1779345031148,"version":"3.51.4"},"reference-count":38,"publisher":"Cold Spring Harbor Laboratory","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1997,11,15]]},"abstract":"<jats:p>The Dorsal morphogen acts as both an activator and a repressor of transcription in the <jats:italic>Drosophila<\/jats:italic> embryo to regulate the expression of dorsal\/ventral patterning genes. Circumstantial evidence has suggested that Dorsal is an intrinsic activator and that additional factors (corepressors) convert it into a repressor. These corepressors, however, have previously eluded definitive identification. We show here, via the analysis of embryos lacking the maternally encoded Groucho corepressor and via protein-binding assays, that recruitment of Groucho to the template by protein:protein interactions is required for the conversion of Dorsal from an activator to a repressor. Groucho is therefore a critical component of the dorsal\/ventral patterning system.<\/jats:p>","DOI":"10.1101\/gad.11.22.2952","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T22:15:26Z","timestamp":1203545726000},"page":"2952-2957","source":"Crossref","is-referenced-by-count":126,"title":["Conversion of Dorsal from an activator to a repressor by the global corepressor\u2009Groucho"],"prefix":"10.1101","volume":"11","author":[{"given":"Todd","family":"Dubnicoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Valentine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze\u2019ev","family":"Paroush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert J.","family":"Courey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[1997,11,15]]},"reference":[{"key":"2021111418483394000_11.22.2952.1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.10.2883"},{"key":"2021111418483394000_11.22.2952.2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.22.2922"},{"key":"2021111418483394000_11.22.2952.3","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.2.190"},{"key":"2021111418483394000_11.22.2952.4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.12.1400"},{"key":"2021111418483394000_11.22.2952.5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0167-4781(94)00234-T","article-title":"The establishment and interpretation of transcription factor gradients in the Drosophila embryo.","volume":"1261","author":"Courey","year":"1995","journal-title":"Biochim. 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