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Therefore, despite the uniform protein composition of the contractile apparatus along the length of the fiber, the loci that encode this structure are not transcribed continuously. The total number of active loci for a particular gene is dynamic, changing during fetal development, regeneration, and in the adult, and potentially reflects the growth status of the fiber. The data reveal that transcription in particular stages of muscle fiber maturation occurs in pulses and is defined by a stochastic mechanism.<\/jats:p>","DOI":"10.1101\/gad.12.17.2748","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T22:15:26Z","timestamp":1203545726000},"page":"2748-2758","source":"Crossref","is-referenced-by-count":163,"title":["Transcription occurs in pulses in muscle fibers"],"prefix":"10.1101","volume":"12","author":[{"given":"Sarah","family":"Newlands","sequence":"first","affiliation":[]},{"given":"Linda K.","family":"Levitt","sequence":"additional","affiliation":[]},{"given":"C. Stephen","family":"Robinson","sequence":"additional","affiliation":[]},{"given":"A.B. 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