{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:16:53Z","timestamp":1779344213370,"version":"3.51.4"},"reference-count":37,"publisher":"Cold Spring Harbor Laboratory","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1998,9,15]]},"abstract":"<jats:p>INK4 and CIP\/KIP are two distinct families of cyclin-dependent kinase (CDK) inhibitors implicated in mediating a wide range of cell growth control signals. We have created p18<jats:sup>INK4c<\/jats:sup>-deficient mice. These mice develop gigantism and widespread organomegaly. The pituitary gland, spleen, and thymus are disproportionately enlarged and hyperplastic. T and B lymphocytes develop normally in p18-deficient mice, but both exhibit increased cellularity and a higher proliferative rate upon mitogenic stimulation. Loss of p18, like that of p27, but not other CDK inhibitor genes, leads to a gradual progression from intermediate lobe pituitary hyperplasia in young mice to an adenoma by 10 months of age with a nearly complete penetrance. Mice lacking both p18 and p27, like mice chimeric for Rb deficiency, invariably died from pituitary adenomas by 3 months. Hence, p18 and p27 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis, likely by controlling the function of Rb.<\/jats:p>","DOI":"10.1101\/gad.12.18.2899","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T22:52:17Z","timestamp":1203547937000},"page":"2899-2911","source":"Crossref","is-referenced-by-count":318,"title":["CDK inhibitors p18<sup>INK4c<\/sup> and p27<sup>Kip1<\/sup> mediate two separate pathways to collaboratively suppress pituitary tumorigenesis"],"prefix":"10.1101","volume":"12","author":[{"given":"David S.","family":"Franklin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia L.","family":"Godfrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grigoriy I.","family":"Kovalev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schoonhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selina","family":"Chen-Kiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lishan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"246","published-online":{"date-parts":[[1998,9,15]]},"reference":[{"key":"2021111418565277000_12.18.2899.1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90039-X"},{"key":"2021111418565277000_12.18.2899.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81239-8"},{"key":"2021111418565277000_12.18.2899.3","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.7.10.1587"},{"key":"2021111418565277000_12.18.2899.4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.24.2939"},{"key":"2021111418565277000_12.18.2899.5","first-page":"1021","article-title":"Heterzygous Rb-1D20\/+ mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance.","volume":"9","author":"Hu","year":"1994","journal-title":"Oncogene"},{"key":"2021111418565277000_12.18.2899.6","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90543-6"},{"key":"2021111418565277000_12.18.2899.7","doi-asserted-by":"publisher","DOI":"10.1038\/359295a0"},{"key":"2021111418565277000_12.18.2899.8","doi-asserted-by":"crossref","unstructured":"Jenkins C.W. 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