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The MGM1 protein has a 200-amino-acid region that is highly related to a family of GTP-binding proteins of apparently diverse function that includes the microtubule-binding protein, dynamin D100. The temperature-sensitive strain partitions mtDNA molecules at the restrictive temperature, but a defect in mtDNA synthesis results in a reduction in the number of molecules per cell at each cell division. On the basis of the results of this study, we conclude that cells can partition single mitochondrial genomes, and that when a cell receives a single molecule at division it is able to restore the normal complement of multiple copies.<\/jats:p>","DOI":"10.1101\/gad.6.3.380","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"380-389","source":"Crossref","is-referenced-by-count":205,"title":["Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin."],"prefix":"10.1101","volume":"6","author":[{"given":"B A","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W L","family":"Fangman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1992,3,1]]},"reference":[{"key":"2021111320212919000_6.3.380.1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.21.9909"},{"key":"2021111320212919000_6.3.380.2","first-page":"851","article-title":"Mx Proteins: Antiviral by chance or by necessity?","volume":"2","year":"1990","journal-title":"The New Biologist"},{"key":"2021111320212919000_6.3.380.3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.13.3963"},{"key":"2021111320212919000_6.3.380.4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.12.120178.002351"},{"key":"2021111320212919000_6.3.380.5","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/j.1460-2075.1989.tb03580.x","article-title":"Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III.","volume":"8","year":"1989","journal-title":"EMBO J."},{"key":"2021111320212919000_6.3.380.6","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.14.5647"},{"key":"2021111320212919000_6.3.380.7","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(82)90384-1"},{"key":"2021111320212919000_6.3.380.8","doi-asserted-by":"publisher","DOI":"10.1038\/351583a0"},{"key":"2021111320212919000_6.3.380.9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.7.1991"},{"key":"2021111320212919000_6.3.380.10","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8924(91)90090-V"},{"key":"2021111320212919000_6.3.380.11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.7.1814"},{"key":"2021111320212919000_6.3.380.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.17.7864"},{"key":"2021111320212919000_6.3.380.13","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1951.016.01.007"},{"key":"2021111320212919000_6.3.380.14","first-page":"1917","article-title":"Stable maintenance of a 35-base-pair yeast mitochondrial genome.","volume":"9","year":"1989","journal-title":"Mol. 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