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In these domains ap is highly similar to the mec-3 and lin-11 proteins of Caenorhabditis elegans and to the vertebrate insulin enhancer-binding protein isl-1. ap is presumably required for transcriptional regulation of genes involved in wing and haltere development. The nature of the defects in homozygous null mutant flies is consistent with the pattern of ap expression in the larval imaginal discs. ap is also expressed in a complex pattern in the embryo, including portions of the peripheral nervous system (PNS) and central nervous system (CNS). A requirement for ap expression in the larval and adult CNS may be the underlying cause of the defects in hormone production and vitellogenesis described for ap mutations.<\/jats:p>","DOI":"10.1101\/gad.6.5.715","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"715-729","source":"Crossref","is-referenced-by-count":326,"title":["apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins."],"prefix":"10.1101","volume":"6","author":[{"given":"B","family":"Cohen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"McGuffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Pfeifle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S M","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"246","published-online":{"date-parts":[[1992,5,1]]},"reference":[{"key":"2021111320222301000_6.5.715.1","doi-asserted-by":"publisher","DOI":"10.1016\/0303-7207(91)90219-I"},{"key":"2021111320222301000_6.5.715.2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(88)90062-0"},{"key":"2021111320222301000_6.5.715.3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1242\/dev.113.1.79","article-title":"Cells with persistent twist expression are the embryonic precursors of adult muscles in Drosophila.","volume":"113","year":"1991","journal-title":"Development"},{"key":"2021111320222301000_6.5.715.4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.9.1288"},{"key":"2021111320222301000_6.5.715.5","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.9.1273"},{"key":"2021111320222301000_6.5.715.6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402027"},{"key":"2021111320222301000_6.5.715.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.1981.tb01108.x"},{"key":"2021111320222301000_6.5.715.8","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/genetics\/52.6.1153","article-title":"The developmental genetics of ap mutants of Drosophila melanogaster.","volume":"52","year":"1965","journal-title":"Genetics"},{"key":"2021111320222301000_6.5.715.9","unstructured":"Bryant, P.J. 1978. 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