{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:19:41Z","timestamp":1775625581463,"version":"3.50.1"},"reference-count":50,"publisher":"Cold Spring Harbor Laboratory","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Dev."],"published-print":{"date-parts":[[1995,11,15]]},"abstract":"<jats:p>Transcription factors belonging to the NF-kappa B family are controlled by inhibitory I kappa B proteins, mainly I kappa B alpha and I kappa B beta. Apparently normal at birth, I kappa B alpha-\/- mice exhibit severe runting, skin defects, and extensive granulopoiesis postnatally, typically dying by 8 days. Hematopoietic tissues from these mice display elevated levels of both nuclear NF-kappa B and mRNAs of some, but not all, genes thought to be regulated by NF-kappa B. NF-kappa B elevation results in these phenotypic abnormalities because mice lacking both I kappa B alpha and the p50 subunit of NF-kappa B show a dramatically delayed onset of abnormalities. In contrast to hematopoietic cells, I kappa B alpha-\/- embryonic fibroblasts show minimal constitutive NF-kappa B, as well as normal signal-dependent NF-kappa B activation that is concomitant with I kappa B beta degradation. Our results indicate that I kappa b beta, but not I kappa B alpha, is required for the signal-dependent activation of NF-kappa B in fibroblasts. However, I kappa B alpha is required for the postinduction repression of NF-kappa B in fibroblasts. These results define distinct roles for the two forms of I kappa B and demonstrate the necessity for stringent control of NF-kappa B.<\/jats:p>","DOI":"10.1101\/gad.9.22.2736","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"2736-2746","source":"Crossref","is-referenced-by-count":388,"title":["Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice."],"prefix":"10.1101","volume":"9","author":[{"given":"A A","family":"Beg","sequence":"first","affiliation":[]},{"given":"W C","family":"Sha","sequence":"additional","affiliation":[]},{"given":"R T","family":"Bronson","sequence":"additional","affiliation":[]},{"given":"D","family":"Baltimore","sequence":"additional","affiliation":[]}],"member":"246","published-online":{"date-parts":[[1995,11,15]]},"reference":[{"key":"2021111418263442000_9.22.2736.1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(93)90377-F"},{"key":"2021111418263442000_9.22.2736.2","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1128\/MCB.15.5.2689","article-title":"Inducible nuclear expression of newly synthesized I\u03baB\u03b1 negatively regulates DNA-binding and transcriptional activities of NF-\u03baB.","volume":"15","year":"1995","journal-title":"Mol. 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