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The wild-type gene, CSE4, is essential for cell division and encodes a protein containing a domain that is 64% identical to the highly conserved chromatin protein, histone H3. Biochemical experiments demonstrate that CSE4p has similar DNA-binding characteristics as those of histone H3 and might form a specialized nucleosome structure in vivo. Interestingly, the human centromere protein, CENP-A, also contains this H3-like domain. Data presented here indicate that CSE4p is required for proper kinetochore function in yeast and may represent an evolutionarily conserved protein necessary for assembly of the unique chromatin structure associated with the eukaryotic centromere.<\/jats:p>","DOI":"10.1101\/gad.9.5.573","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T21:15:46Z","timestamp":1181078146000},"page":"573-586","source":"Crossref","is-referenced-by-count":343,"title":["A mutation in CSE4, an essential gene encoding a novel chromatin-associated protein in yeast, causes chromosome nondisjunction and cell cycle arrest at mitosis."],"prefix":"10.1101","volume":"9","author":[{"given":"S","family":"Stoler","sequence":"first","affiliation":[]},{"given":"K C","family":"Keith","sequence":"additional","affiliation":[]},{"given":"K E","family":"Curnick","sequence":"additional","affiliation":[]},{"given":"M","family":"Fitzgerald-Hayes","sequence":"additional","affiliation":[]}],"member":"246","published-online":{"date-parts":[[1995,3,1]]},"reference":[{"key":"2021111418211018000_9.5.573.1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.22.10148"},{"key":"2021111418211018000_9.5.573.2","first-page":"2458","article-title":"Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1.","volume":"10","year":"1990","journal-title":"Mol. 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