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In vivo, derepression of silenced rRNA genes upon knockdown of <jats:italic>HDA6<\/jats:italic> is accompanied by nucleolus organizer region (NOR) decondensation, loss of promoter cytosine methylation, and replacement of histone H3 Lys 9 (H3K9) dimethylation with H3K4 trimethylation, H3K9 acetylation, H3K14 acetylation, and histone H4 tetra-acetylation. Consistent with these in vivo results, purified HDA6 deacetylates lysines modified by histone acetyltransferases whose substrates include H3K14, H4K5, and H4K12. HDA6 localizes, in part, to the nucleolus, supporting a model whereby HDA6 erases histone acetylation as a key step in an epigenetic switch mechanism that silences rRNA genes through concerted histone and DNA modifications.<\/jats:p>","DOI":"10.1101\/gad.1417706","type":"journal-article","created":{"date-parts":[[2006,4,29]],"date-time":"2006-04-29T00:50:37Z","timestamp":1146271837000},"page":"1283-1293","source":"Crossref","is-referenced-by-count":205,"title":["Erasure of histone acetylation by <i>Arabidopsis HDA6<\/i> mediates large-scale gene silencing in nucleolar dominance"],"prefix":"10.1101","volume":"20","author":[{"given":"Keith","family":"Earley","sequence":"first","affiliation":[]},{"given":"Richard J.","family":"Lawrence","sequence":"additional","affiliation":[]},{"given":"Olga","family":"Pontes","sequence":"additional","affiliation":[]},{"given":"Rachel","family":"Reuther","sequence":"additional","affiliation":[]},{"given":"Angel 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