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Neuronal\n                    <jats:italic>bet-1<\/jats:italic>\n                    elicits a neurotransmitter-dependent signal that activates the conserved stress-responsive transcription factor HSF-1 in the intestine, enhancing proteostasis, oxidative stress resistance, metabolic remodeling, and immune defense. Life span extension by neuronal\n                    <jats:italic>bet-1<\/jats:italic>\n                    requires both\n                    <jats:italic>hsf-1<\/jats:italic>\n                    and\n                    <jats:italic>daf-16<\/jats:italic>\n                    in neurons but only requires\n                    <jats:italic>hsf-1<\/jats:italic>\n                    in peripheral tissues. Using bulk RNA sequencing, we reveal distinct prolongevity pathways that include enhanced heat-shock response, proteostasis, increased actin stability, and resistance to pathogens, which likely together coordinate the prolongevity effects of neuronal\n                    <jats:italic>bet-1<\/jats:italic>\n                    . Our findings establish BET-1 as a potent nonautonomous regulator of aging and stress response, highlighting chromatin readers as upstream modulators of intertissue signaling and systemic resilience.\n                  <\/jats:p>","DOI":"10.1101\/gad.353559.125","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:10:17Z","timestamp":1786029017000},"page":"1523-1552","source":"Crossref","is-referenced-by-count":0,"title":["Neuronal expression of bromodomain proteins alters neuronal health and peripheral protein homeostasis to promote longevity"],"prefix":"10.1101","volume":"40","author":[{"given":"Naibedya","family":"Dutta","sequence":"first","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California 90089, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Hicks","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, 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