{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:41:38Z","timestamp":1791261698371,"version":"4.1.0"},"reference-count":35,"publisher":"American Physical Society (APS)","issue":"2","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/link.aps.org\/licenses\/aps-default-license"},{"start":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T00:00:00Z","timestamp":1487376000000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/link.aps.org\/licenses\/aps-default-accepted-manuscript-license"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["PHY11-25915"],"award-info":[{"award-number":["PHY11-25915"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-12-06323"],"award-info":[{"award-number":["DMR-12-06323"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phys. Rev. E"],"DOI":"10.1103\/physreve.93.022412","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T18:31:00Z","timestamp":1455906660000},"source":"Crossref","is-referenced-by-count":40,"title":["Identification of drug resistance mutations in HIV from constraints on natural evolution"],"prefix":"10.1103","volume":"93","author":[{"given":"Thomas C.","family":"Butler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Kardar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arup K.","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"PhysRevE.93.022412Cc1R1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0796-760"},{"key":"PhysRevE.93.022412Cc2R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60676-9"},{"key":"PhysRevE.93.022412Cc3R1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283388742"},{"key":"PhysRevE.93.022412Cc4R1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1246"},{"key":"PhysRevE.93.022412Cc5R1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7824947"},{"key":"PhysRevE.93.022412Cc6R1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5255.1582"},{"key":"PhysRevE.93.022412Cc7R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105315108"},{"key":"PhysRevE.93.022412Cc8R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.022"},{"key":"PhysRevE.93.022412Cc9R1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.795"},{"key":"PhysRevE.93.022412Cc10R1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.7.3722-3732.2004"},{"key":"PhysRevE.93.022412Cc11R1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(05)03377-5"},{"key":"PhysRevE.93.022412Cc12R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.112177799"},{"key":"PhysRevE.93.022412Cc13R1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00623322"},{"key":"PhysRevE.93.022412Cc14R1","doi-asserted-by":"publisher","DOI":"10.1063\/1.450436"},{"key":"PhysRevE.93.022412Cc15R1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.88.062705"},{"key":"PhysRevE.93.022412Cc16R1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg100"},{"key":"PhysRevE.93.022412Cc17R1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRev.106.620"},{"key":"PhysRevE.93.022412Cc18R1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.106.090601"},{"key":"PhysRevE.93.022412Cc19R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111471108"},{"key":"PhysRevE.93.022412Cc20R1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04701"},{"key":"PhysRevE.93.022412Cc21R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805923106"},{"key":"PhysRevE.93.022412Cc22R1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2419"},{"key":"PhysRevE.93.022412Cc23R1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-5468\/2013\/03\/p03002"},{"key":"PhysRevE.93.022412Cc24R1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003776"},{"key":"PhysRevE.93.022412Cc25R1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090727"},{"key":"PhysRevE.93.022412Cc26R1","first-page":"125","volume":"8","author":"P. Lemey","year":"2006","journal-title":"AIDS Rev."},{"key":"PhysRevE.93.022412Cc27R1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000660"},{"key":"PhysRevE.93.022412Cc28R1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.01123"},{"key":"PhysRevE.93.022412Cc29R1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000906"},{"key":"PhysRevE.93.022412Cc30R1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00694-10"},{"key":"PhysRevE.93.022412Cc31R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.03.038"},{"key":"PhysRevE.93.022412Cc32R1","doi-asserted-by":"publisher","DOI":"10.1086\/386291"},{"key":"PhysRevE.93.022412Cc33R1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1660"},{"key":"PhysRevE.93.022412Cc34R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61038-1"},{"key":"PhysRevE.93.022412Cc35R1","volume-title":"HIV-1 Subtype and Circulating Recombinant form (CRF) Reference Sequences","author":"T. Leitner","year":"2005"}],"container-title":["Physical Review E"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.aps.org\/accepted\/10.1103\/PhysRevE.93.022412","content-type":"application\/pdf","content-version":"am","intended-application":"unspecified"},{"URL":"http:\/\/link.aps.org\/article\/10.1103\/PhysRevE.93.022412","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/harvest.aps.org\/v2\/journals\/articles\/10.1103\/PhysRevE.93.022412\/fulltext","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T11:33:24Z","timestamp":1491478404000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.aps.org\/doi\/10.1103\/PhysRevE.93.022412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"URL":"https:\/\/doi.org\/10.1103\/physreve.93.022412","relation":{},"ISSN":["2470-0045","2470-0053"],"issn-type":[{"value":"2470-0045","type":"print"},{"value":"2470-0053","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]},"article-number":"022412"}}