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Rev. E"],"accepted":{"date-parts":[[2026,5,26]]},"abstract":"<jats:p>Run-and-tumble particles constitute one of the simplest models of self-propelled active matter, and provide an ideal playground for the understanding of out-of-equilibrium systems. We consider an idealized setup where one such particle is subject to a harmonic confining potential, and an external agent can vary in time the tumbling rate and the strength of the trap. We search for time-dependent control protocols steering the system between assigned end states, in a prescribed time interval. To this aim, we propose a description of the dynamics, alternative to the usual ones, in the form of an infinite set of ordinary differential equations. Solutions based on a suitable closure of such hierarchy, which we expect to hold true in the limit of long protocol duration, are discussed and compared with numerical simulations. We also look for the protocol completing the task with the minimal work, on average: the problem can be tackled analytically, again in the regime of slow (but not quasistatic) transformations. 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