{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:03:37Z","timestamp":1792811017455,"version":"4.5.0"},"reference-count":50,"publisher":"American Physical Society (APS)","issue":"13","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/link.aps.org\/licenses\/aps-default-license"}],"funder":[{"DOI":"10.13039\/100012952","name":"Universit\u00e9 Grenoble Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010115","name":"R\u00e9gion Auvergne-Rh\u00f4ne-Alpes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1027\/A13"],"award-info":[{"award-number":["SFB 1027\/A13"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005690","name":"Universit\u00e4t des Saarlandes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005690","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.aps.org"],"crossmark-restriction":true},"short-container-title":["Phys. Rev. Lett."],"accepted":{"date-parts":[[2026,8,26]]},"DOI":"10.1103\/zykj-2361","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:32:58Z","timestamp":1787754778000},"update-policy":"https:\/\/doi.org\/10.1103\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond the Tip: Lattice Dynamics, Seams, and the Mechanism of Microtubule Fracture"],"prefix":"10.1103","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9250-3137","authenticated-orcid":true,"given":"Amir","family":"Zablotsky","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02rx3b187","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 Grenoble-Alpes"},{"id":[{"id":"https:\/\/ror.org\/04px4e658","id-type":"ROR","asserted-by":"publisher"}],"name":"CNRS"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6117-3040","authenticated-orcid":true,"given":"Subham","family":"Biswas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01jdpyv68","id-type":"ROR","asserted-by":"publisher"}],"name":"Saarland University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7317-3696","authenticated-orcid":true,"given":"Laura","family":"Schaedel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01jdpyv68","id-type":"ROR","asserted-by":"publisher"}],"name":"Saarland University"},{"name":"PharmaScienceHub (PSH)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1678-6880","authenticated-orcid":true,"given":"Karin","family":"John","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02rx3b187","id-type":"ROR","asserted-by":"publisher"}],"name":"Universit\u00e9 Grenoble-Alpes"},{"id":[{"id":"https:\/\/ror.org\/04px4e658","id-type":"ROR","asserted-by":"publisher"}],"name":"CNRS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"zykj-2361Cc1R1","volume-title":"Molecular Biology of the Cell","author":"B. Alberts","year":"2022","type":"book"},{"key":"zykj-2361Cc2R1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00399-x","type":"journal-article"},{"key":"zykj-2361Cc3R1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197354","type":"journal-article"},{"key":"zykj-2361Cc4R1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225650","type":"journal-article"},{"key":"zykj-2361Cc5R1","doi-asserted-by":"publisher","DOI":"10.1038\/312237a0","type":"journal-article"},{"key":"zykj-2361Cc6R1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4084","type":"journal-article"},{"key":"zykj-2361Cc7R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.02.035","type":"journal-article"},{"key":"zykj-2361Cc8R1","doi-asserted-by":"publisher","DOI":"10.1002\/cm.970210302","type":"journal-article"},{"key":"zykj-2361Cc9R1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4396","type":"journal-article"},{"key":"zykj-2361Cc10R1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3406","type":"journal-article"},{"key":"zykj-2361Cc11R1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1504","type":"journal-article"},{"key":"zykj-2361Cc12R1","doi-asserted-by":"publisher","DOI":"10.1038\/s41567-019-0542-4","type":"journal-article"},{"key":"zykj-2361Cc13R1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563-020-00905-0","type":"journal-article"},{"key":"zykj-2361Cc14R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2208294119","type":"journal-article"},{"key":"zykj-2361Cc15R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.11.019","type":"journal-article"},{"key":"zykj-2361Cc16R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.04.020","type":"journal-article"},{"key":"zykj-2361Cc17R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.11.060","type":"journal-article"},{"key":"zykj-2361Cc18R1","doi-asserted-by":"publisher","DOI":"10.1038\/s41567-025-03003-7","type":"journal-article"},{"key":"zykj-2361Cc19R1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201612104","type":"journal-article"},{"key":"zykj-2361Cc20R1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-142844","type":"journal-article"},{"key":"zykj-2361Cc21R1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.09.08.672697","type":"journal-article"},{"key":"zykj-2361Cc22R1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83021","type":"journal-article"},{"key":"zykj-2361Cc23R1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.58.2598","type":"journal-article"},{"key":"zykj-2361Cc24R1","unstructured":"See Supplemental Material at http:\/\/link.aps.org\/supplemental\/10.1103\/zykj-2361 for details of the kinetic Monte\u00a0Carlo simulations, the calibration of the timescale \u03c4, additional simulations of the damge size and time to fracture, and a discussion of literature values for A and \u0394Gb.","type":"other"},{"key":"zykj-2361Cc25R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.092504999","type":"journal-article"},{"key":"zykj-2361Cc26R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.053","type":"journal-article"},{"key":"zykj-2361Cc27R1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-08-0688","type":"journal-article"},{"key":"zykj-2361Cc28R1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e16-03-0199","type":"journal-article"},{"key":"zykj-2361Cc29R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.08.023","type":"journal-article"},{"key":"zykj-2361Cc30R1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815823116","type":"journal-article"},{"key":"zykj-2361Cc31R1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.54253","type":"journal-article"},{"key":"zykj-2361Cc32R1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.89231.3","type":"journal-article"},{"key":"zykj-2361Cc33R1","unstructured":"We favor here the measure (2) over a more classical definition of the anisotropy (\u0394Glong\u2212\u0394Glat)\/(\u0394Glong+\u0394Glat) since it facilitates a direct comparison with data in the literature.","type":"other"},{"key":"zykj-2361Cc34R1","doi-asserted-by":"crossref","DOI":"10.1002\/9781118698723","type":"book","volume-title":"Modern Thermodynamics: From Heat Engines to Dissipative Structures","author":"D. Kondepudi","year":"2014"},{"key":"zykj-2361Cc35R1","unstructured":"Note that in the perfect lattice the first vacancy is created by the spontaneous loss of a dimer with two longitudinal and four lateral monomer neighbors.","type":"other"},{"key":"zykj-2361Cc36R1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.102.6.2023","type":"journal-article"},{"key":"zykj-2361Cc37R1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.107.4.1437","type":"journal-article"},{"key":"zykj-2361Cc38R1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.118.5.1097","type":"journal-article"},{"key":"zykj-2361Cc39R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2023.01.020","type":"journal-article"},{"key":"zykj-2361Cc40R1","doi-asserted-by":"publisher","DOI":"10.1110\/ps.03187503","type":"journal-article"},{"key":"zykj-2361Cc41R1","doi-asserted-by":"publisher","DOI":"10.1021\/ja506385p","type":"journal-article"},{"key":"zykj-2361Cc42R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2019.08.011","type":"journal-article"},{"key":"zykj-2361Cc43R1","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.105.060913","type":"journal-article"},{"key":"zykj-2361Cc44R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.05.059","type":"journal-article"},{"key":"zykj-2361Cc45R1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2015.10.048","type":"journal-article"},{"key":"zykj-2361Cc46R1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201802138","type":"journal-article"},{"key":"zykj-2361Cc47R1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17553-2","type":"journal-article"},{"key":"zykj-2361Cc48R1","doi-asserted-by":"publisher","DOI":"10.1039\/C8NR07392A","type":"journal-article"},{"key":"zykj-2361Cc49R1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4094","type":"journal-article"},{"key":"zykj-2361Cc50R1","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.22129045","type":"dataset"}],"container-title":["Physical Review Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.aps.org\/article\/10.1103\/zykj-2361","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/harvest.aps.org\/v2\/journals\/articles\/10.1103\/zykj-2361\/fulltext","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:29:48Z","timestamp":1790879388000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.aps.org\/doi\/10.1103\/zykj-2361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":50,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1103\/zykj-2361","relation":{},"ISSN":["0031-9007","1079-7114"],"issn-type":[{"value":"0031-9007","type":"print"},{"value":"1079-7114","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]},"assertion":[{"value":"2025-11-12","name":"date_received","label":"Date Received","group":{"name":"publication_dates","label":"Publication dates"}},{"value":"\u00a9 2026 American Physical Society. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright_statement","label":"Copyright statement","group":{"name":"copyright","label":"copyright"}},{"value":"2026","name":"copyright_year","label":"Copyright year","group":{"name":"copyright","label":"copyright"}},{"value":"American Physical Society","name":"copyright_holder","label":"Copyright holder","group":{"name":"copyright","label":"copyright"}}],"article-number":"138401"}}