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At this stage, nitrogen application has no effect on dhurrin content, whereas in older plants, nitrogen application induces an increase. At all stages, the content of dhurrin correlates well with the activity of the two biosynthetic enzymes, CYP79A1 and CYP71E1, and with the protein and mRNA level for the two enzymes. During development, the activity of CYP79A1 is lower than the activity of CYP71E1, suggesting that CYP79A1 catalyzes the rate-limiting step in dhurrin synthesis as has previously been shown using etiolated seedlings. The site of dhurrin synthesis shifts from leaves to stem during plant development. In combination, the results demonstrate that dhurrin content in sorghum is largely determined by transcriptional regulation of the biosynthetic enzymes CYP79A1 and CYP71E1.<\/jats:p>","DOI":"10.1104\/pp.000687","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T22:44:09Z","timestamp":1027896249000},"page":"1222-1231","source":"Crossref","is-referenced-by-count":162,"title":["Dhurrin Synthesis in Sorghum Is Regulated at the Transcriptional Level and Induced by Nitrogen Fertilization in Older Plants"],"prefix":"10.1093","volume":"129","author":[{"given":"Peter Kamp","family":"Busk","sequence":"first","affiliation":[{"name":"Plant Biochemistry Laboratory, Department of Plant Biology, and Center for Molecular Plant Physiology, Royal Veterinary and Agricultural University, 40 Thorvaldsensvej, DK\u20131871 Frederiksberg C, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birger Lindberg","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Plant Biochemistry Laboratory, Department of Plant Biology, and Center for Molecular Plant Physiology, Royal Veterinary and Agricultural University, 40 Thorvaldsensvej, DK\u20131871 Frederiksberg C, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"2021062512552478300_R1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1104\/pp.94.3.1219","article-title":"Turnover of dhurrin in green sorghum seedlings.","volume":"94","author":"Adewusi","year":"1990","journal-title":"Plant Physiol"},{"key":"2021062512552478300_R2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1104\/pp.35.4.535","article-title":"Studies on cyanogenic glycosides of Sorghum vulgare.","volume":"35","author":"Akazawa","year":"1960","journal-title":"Plant Physiol"},{"key":"2021062512552478300_R3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1104\/pp.127.1.108","article-title":"The involvement of two P450 enzymes, CYP83B1 and CYP83A1, in auxin homeostasis and glucosinolate biosynthesis.","volume":"127","author":"Bak","year":"2001","journal-title":"Plant Physiol"},{"key":"2021062512552478300_R4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1023\/A:1005915507497","article-title":"Cloning three A-type cytochromes P450, CYP71E1, CYP98, and CYP99 from Sorghum bicolor L. 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