{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:34:52Z","timestamp":1775306092143,"version":"3.50.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2003,8,1]],"date-time":"2003-08-01T00:00:00Z","timestamp":1059696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The E2F family plays a pivotal role in cell cycle control and is conserved among plants and animals, but not in fungi. This provides for the possibility that the E2F family was integrated during the development of higher organisms, but little is known about this. We examined the effect of E2F ectopically expressed in transgenic tobacco (Nicotiana tabacum) plants on growth and development using E2Fa (AtE2F3) and DPa from Arabidopsis. E2Fa-DPa double transgenic lines exhibited altered phenotypes with curled leaves, round shaped petals, and shortened pistils. In mature but not immature leaves of the double transgenic lines, there were enlarged nuclei with increasing ploidy levels accompanied by the ectopic expression of S phase- but not M phase-specific genes. This indicates that a high expression of E2F promotes endoreduplication by accelerating S phase entry in terminally differentiated cells with limited mitotic activity. Furthermore, mature leaves of the transgenic plants contained increased numbers of small cells, especially on the palisade (adaxial) side of the outer region toward the edge, and the leaf strips exhibited hormone-independent callus formation when cultured in vitro. These observations suggest that an enhanced E2F activity modulates cell cycle in a cell type-specific manner and affects plant morphology depending on a balance between activities for committing to S phase and M phase, which likely differ between organs or tissues.<\/jats:p>","DOI":"10.1104\/pp.103.025080","type":"journal-article","created":{"date-parts":[[2003,8,12]],"date-time":"2003-08-12T02:35:30Z","timestamp":1060655730000},"page":"2012-2022","source":"Crossref","is-referenced-by-count":61,"title":["Constitutive E2F Expression in Tobacco Plants Exhibits Altered Cell Cycle Control and Morphological Change in a Cell Type-Specific Manner"],"prefix":"10.1093","volume":"132","author":[{"given":"Shunichi","family":"Kosugi","sequence":"first","affiliation":[{"name":"Plant Physiology Department, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305\u20138602, Japan; and Core Research for Evolutional Science and Technology, JST, Ochanomizu, Chiyoda-ku, Tokyo 101\u20130062, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Plant Physiology Department, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305\u20138602, Japan; and Core Research for Evolutional Science and Technology, JST, Ochanomizu, Chiyoda-ku, Tokyo 101\u20130062, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,8,11]]},"reference":[{"key":"2021062515212428700_REF1","doi-asserted-by":"crossref","unstructured":"Albani D, Mariconti L, Ricagno S, Pitto L, Moroni C, Helin K, Cella R (2000) DcE2F, a functional plant E2F-like transcriptional activator from Daucus carota. \u00a0J Biol Chem \u00a0275\n\u00a0: \u00a019258\u201319267","DOI":"10.1074\/jbc.M909390199"},{"key":"2021062515212428700_REF2","doi-asserted-by":"crossref","unstructured":"Asano M, Nevins JR, Wharton RP (1996) Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev \u00a010\n\u00a0: \u00a01422\u20131432","DOI":"10.1101\/gad.10.11.1422"},{"key":"2021062515212428700_REF3","doi-asserted-by":"crossref","unstructured":"Chaboute ME, Clement B, Philipps G (2002) S phase and meristem-specific expression of the tobacco RNR1b gene is mediated by an E2F element located in the 5\u2032 leader sequence. J Biol Chem \u00a0277\n\u00a0: \u00a017845\u201317851","DOI":"10.1074\/jbc.M200959200"},{"key":"2021062515212428700_REF4","doi-asserted-by":"crossref","unstructured":"Chaboute ME, Clement B, Sekine M, Philipps G, Chaubet-Gigot N (2000) Cell cycle regulation of the tobacco ribonucleotide reductase small subunit gene is mediated by E2F-like elements. Plant Cell \u00a012\n\u00a0: \u00a01987\u20132000","DOI":"10.2307\/3871208"},{"key":"2021062515212428700_REF5","doi-asserted-by":"crossref","unstructured":"Cockcroft CE, den Boer BG, Healy JM, Murray JA (2000) Cyclin D control of growth rate in plants. Nature \u00a0405\n\u00a0: \u00a0575\u2013579","DOI":"10.1038\/35014621"},{"key":"2021062515212428700_REF6","doi-asserted-by":"crossref","unstructured":"DeGregori J (2002) The genetics of the E2F family of transcription factors: shared functions and unique roles. Biochim Biophys Acta \u00a01602\n\u00a0: \u00a0131\u2013150","DOI":"10.1016\/S0304-419X(02)00051-3"},{"key":"2021062515212428700_REF7","doi-asserted-by":"crossref","unstructured":"de Jager SM, Menges M, Bauer UM, Murra JA (2001) Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities. Plant Mol Biol \u00a047\n\u00a0: \u00a0555\u2013568","DOI":"10.1023\/A:1011848528377"},{"key":"2021062515212428700_REF8","doi-asserted-by":"crossref","unstructured":"Del Pozo JC, Boniotti MB, Gutierrez C (2002) Arabidopsis E2Fc functions in cell division and is degraded by the ubiquitin-SCF(AtSKP2) pathway in response to light. Plant Cell \u00a014\n\u00a0: \u00a03057\u20133071","DOI":"10.1105\/tpc.006791"},{"key":"2021062515212428700_REF9","doi-asserted-by":"crossref","unstructured":"De Veylder L, Beeckman T, Beemster GT, de Almeida Engler J, Ormenese \u00a0S, Maes S, Naudts M, Van Der Schueren E, Jacqmard A et al. (2002) Control of proliferation, endoreduplication and differentiation by the Arabidopsis E2Fa-DPa transcription factor. EMBO J \u00a021\n\u00a0: \u00a01360\u20131368","DOI":"10.1093\/emboj\/21.6.1360"},{"key":"2021062515212428700_REF10","doi-asserted-by":"crossref","unstructured":"Du W, Xie JE, Dyson N (1996) Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J \u00a015\n\u00a0: \u00a03684\u20133692","DOI":"10.1002\/j.1460-2075.1996.tb00738.x"},{"key":"2021062515212428700_REF11","doi-asserted-by":"crossref","unstructured":"Dyson N (1998) The regulation of E2F by pRB-family proteins. Genes Dev \u00a012\n\u00a0: \u00a02245\u20132262","DOI":"10.1101\/gad.12.15.2245"},{"key":"2021062515212428700_REF12","doi-asserted-by":"crossref","unstructured":"Edgar BA, Orr-Weaver TL (2001) Endoreplication cell cycles: more for less. Cell \u00a0105\n\u00a0: \u00a0297\u2013306","DOI":"10.1016\/S0092-8674(01)00334-8"},{"key":"2021062515212428700_REF13","doi-asserted-by":"crossref","unstructured":"Egelkrout EM, Mariconti L, Settlage SB, Cella R, Robertson D, Hanley-Bowdoin L (2002) Two E2F elements regulate the proliferating cell nuclear antigen promoter differently during leaf development. Plant Cell \u00a014\n\u00a0: \u00a03225\u20133236","DOI":"10.1105\/tpc.006403"},{"key":"2021062515212428700_REF14","doi-asserted-by":"crossref","unstructured":"Egelkrout EM, Robertson D, Hanley-Bowdoin L (2001) Proliferating cell nuclear antigen transcription is repressed through an E2F consensus element and activated by geminivirus infection in mature leaves. Plant Cell \u00a013\n\u00a0: \u00a01437\u20131452","DOI":"10.1105\/tpc.13.6.1437"},{"key":"2021062515212428700_REF15","doi-asserted-by":"crossref","unstructured":"Fobert PR, Coen ES, Murphy GJ, Doonan JH (1994) Patterns of cell division revealed by transcriptional regulation of genes during the cell cycle in plants. EMBO J \u00a013\n\u00a0: \u00a0616\u2013624","DOI":"10.1002\/j.1460-2075.1994.tb06299.x"},{"key":"2021062515212428700_REF16","doi-asserted-by":"crossref","unstructured":"Franceschi V (2001) Calcium oxalate in plants. Trends Plant Sci \u00a06\n\u00a0: \u00a0331","DOI":"10.1016\/S1360-1385(01)02014-3"},{"key":"2021062515212428700_REF17","doi-asserted-by":"crossref","unstructured":"Galbraith DWHK, Maddox JM, Ayres NM, Sharma DP, Firoozabadi E (1983) Rapid flow cytometric analysis of the cell cycle in intact plant tissues. Science \u00a0220\n\u00a0: \u00a01049\u20131051","DOI":"10.1126\/science.220.4601.1049"},{"key":"2021062515212428700_REF18","doi-asserted-by":"crossref","unstructured":"Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM, \u00a0Rempel RE (2000) E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell \u00a06\n\u00a0: \u00a0729\u2013735","DOI":"10.1016\/S1097-2765(00)00071-X"},{"key":"2021062515212428700_REF19","doi-asserted-by":"crossref","unstructured":"Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR (2001) Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol \u00a021\n\u00a0: \u00a04684\u20134699","DOI":"10.1128\/MCB.21.14.4684-4699.2001"},{"key":"2021062515212428700_REF20","doi-asserted-by":"crossref","unstructured":"Johnson DG, Schwarz JK, Cress WD, Nevins JR (1993) Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature \u00a0365\n\u00a0: \u00a0349\u2013352","DOI":"10.1038\/365349a0"},{"key":"2021062515212428700_REF21","doi-asserted-by":"crossref","unstructured":"Joubes J, Chevalier C (2000) Endoreduplication in higher plants. Plant Mol Biol \u00a043\n\u00a0: \u00a0735\u2013745","DOI":"10.1023\/A:1006446417196"},{"key":"2021062515212428700_REF22","doi-asserted-by":"crossref","unstructured":"Kong LJ, Orozco BM, Roe JL, Nagar S, Ou S, Feiler HS, Durfee T, Miller \u00a0AB, Gruissem W, Robertson D et al. (2000) A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants. EMBO J \u00a019\n\u00a0: \u00a03485\u20133495","DOI":"10.1093\/emboj\/19.13.3485"},{"key":"2021062515212428700_REF23","doi-asserted-by":"crossref","unstructured":"Kosugi S, Ohashi Y (1997) PCF1 and PCF2 specifically bind to cis elements in the rice proliferating cell nuclear antigen gene. Plant Cell \u00a09\n\u00a0: \u00a01607\u20131619","DOI":"10.1105\/tpc.9.9.1607"},{"key":"2021062515212428700_REF24","doi-asserted-by":"crossref","unstructured":"Kosugi S, Ohashi Y (2000) Cloning and DNA-binding properties of a tobacco ethylene-insensitive3 (EIN3) homolog. Nucleic Acids Res \u00a028\n\u00a0: \u00a0960\u2013967","DOI":"10.1093\/nar\/28.4.960"},{"key":"2021062515212428700_REF25","doi-asserted-by":"crossref","unstructured":"Kosugi S, Ohashi Y (2002a) E2F sites that can interact with E2F proteins cloned from rice are required for meristematic tissue-specific expression of rice and tobacco proliferating cell nuclear antigen promoters. Plant J \u00a029\n\u00a0: \u00a045\u201359","DOI":"10.1046\/j.1365-313x.2002.01196.x"},{"key":"2021062515212428700_REF26","doi-asserted-by":"crossref","unstructured":"Kosugi S, Ohashi Y (2002b) E2Ls, E2F-like repressors of Arabidopsis that bind to E2F sites in a monomeric form. J Biol Chem \u00a0277\n\u00a0: \u00a016553\u201316558","DOI":"10.1074\/jbc.M200913200"},{"key":"2021062515212428700_REF27","doi-asserted-by":"crossref","unstructured":"Kosugi S, Ohashi Y (2002c) Interaction of the Arabidopsis E2F and DP proteins confers their concomitant nuclear translocation and transactivation. Plant Physiol \u00a0128\n\u00a0: \u00a0833\u2013843","DOI":"10.1104\/pp.010642"},{"key":"2021062515212428700_REF28","doi-asserted-by":"crossref","unstructured":"Kosugi S, Suzuka I, Ohashi Y, Murakami T, Arai Y (1991) Upstream sequences of rice proliferating cell nuclear antigen (PCNA) gene mediate expression of PCNA-GUS chimeric gene in meristems of transgenic tobacco plants. Nucleic Acids Res \u00a019\n\u00a0: \u00a01571\u20131576","DOI":"10.1093\/nar\/19.7.1571"},{"key":"2021062515212428700_REF29","doi-asserted-by":"crossref","unstructured":"Kouchi H, Sekine M, Hata S (1995) Distinct classes of mitotic cyclins are differentially expressed in the soybean shoot apex during the cell cycle. Plant Cell \u00a07\n\u00a0: \u00a01143\u20131155","DOI":"10.1105\/tpc.7.8.1143"},{"key":"2021062515212428700_REF30","doi-asserted-by":"crossref","unstructured":"Lavia P, Jansen-Du\u0308rr P (1999) E2F target genes and cell-cycle checkpoint control. Bioessays \u00a021\n\u00a0: \u00a0221\u2013230","DOI":"10.1002\/(SICI)1521-1878(199903)21:3<221::AID-BIES6>3.0.CO;2-J"},{"key":"2021062515212428700_REF31","doi-asserted-by":"crossref","unstructured":"Lindeman GJ, Dagnino L, Gaubatz S, Xu Y, Bronson RT, Warren HB, \u00a0Livingston DM (1998) A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev \u00a012\n\u00a0: \u00a01092\u20131098","DOI":"10.1101\/gad.12.8.1092"},{"key":"2021062515212428700_REF32","doi-asserted-by":"crossref","unstructured":"Magyar Z, Atanassova A, De Veylder L, Rombauts S, Inze\u0301 D (2000) Characterization of two distinct DP-related genes from Arabidopsis thaliana. \u00a0FEBS Lett \u00a0486\n\u00a0: \u00a079\u201387","DOI":"10.1016\/S0014-5793(00)02238-9"},{"key":"2021062515212428700_REF33","doi-asserted-by":"crossref","unstructured":"Mariconti L, Pellegrini B, Cantoni R, Stevens R, Bergounioux C, Cella R, \u00a0Albani D (2002) The E2F family of transcription factors from Arabidopsis thaliana: novel and conserved components of the retinoblastoma\/E2F pathway in plants. J Biol Chem \u00a0277\n\u00a0: \u00a09911\u20139919","DOI":"10.1074\/jbc.M110616200"},{"key":"2021062515212428700_REF34","doi-asserted-by":"crossref","unstructured":"Mu\u0308ller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, \u00a0Prosperini E, Vigo E, Oliner JD, Helin K (2001) E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev \u00a015\n\u00a0: \u00a0267\u2013285","DOI":"10.1101\/gad.864201"},{"key":"2021062515212428700_REF35","doi-asserted-by":"crossref","unstructured":"Mu\u0308ller H, Helin K (2000) The E2F transcription factors: key regulators of cell proliferation. Biochim Biophys Acta \u00a01470\n\u00a0: \u00a0M1\u201312","DOI":"10.1016\/S0304-419X(99)00030-X"},{"key":"2021062515212428700_REF36","doi-asserted-by":"crossref","unstructured":"Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant \u00a015\n\u00a0: \u00a0473\u2013497","DOI":"10.1111\/j.1399-3054.1962.tb08052.x"},{"key":"2021062515212428700_REF37","doi-asserted-by":"crossref","unstructured":"Nagar S, Pedersen TJ, Carrick KM, Hanley-Bowdoin L, Robertson D (1995) A geminivirus induces expression of a host DNA synthesis protein in terminally differentiated plant cells. Plant Cell \u00a07\n\u00a0: \u00a0705\u2013719","DOI":"10.1105\/tpc.7.6.705"},{"key":"2021062515212428700_REF38","doi-asserted-by":"crossref","unstructured":"Ogawa H, Ishiguro K, Gaubatz S, Livingston DM, Nakatani Y (2002) A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science \u00a0296\n\u00a0: \u00a01132\u20131136","DOI":"10.1126\/science.1069861"},{"key":"2021062515212428700_REF39","doi-asserted-by":"crossref","unstructured":"Paramio JM, Segrelles C, Casanova ML, Jorcano JL (2000) Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation. J Biol Chem \u00a0275\n\u00a0: \u00a041219\u201341226","DOI":"10.1074\/jbc.M004973200"},{"key":"2021062515212428700_REF40","doi-asserted-by":"crossref","unstructured":"Pascal E, Goodlove PE, Wu LC, Lazarowitz SG (1993) Transgenic tobacco plants expressing the geminivirus BL1 protein exhibit symptoms of viral disease. Plant Cell \u00a05\n\u00a0: \u00a0795\u2013807","DOI":"10.1105\/tpc.5.7.795"},{"key":"2021062515212428700_REF41","doi-asserted-by":"crossref","unstructured":"Qin XQ, Livingston DM, Kaelin WG Jr, Adams PD (1994) Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA \u00a091\n\u00a0: \u00a010918\u201310922","DOI":"10.1073\/pnas.91.23.10918"},{"key":"2021062515212428700_REF42","doi-asserted-by":"crossref","unstructured":"Rami\u0301rez-Parra E, Gutierrez C (2000) Characterization of wheat DP, a heterodimerization partner of the plant E2F transcription factor which stimulates E2F-DNA binding. FEBS Lett \u00a0486\n\u00a0: \u00a073\u201378","DOI":"10.1016\/S0014-5793(00)02239-0"},{"key":"2021062515212428700_REF43","doi-asserted-by":"crossref","unstructured":"Rami\u0301rez-Parra E, Xie Q, Boniotti MB, Gutierrez C (1999) The cloning of plant E2F, a retinoblastoma-binding protein, reveals unique and conserved features with animal G(1)\/S regulators. Nucleic Acids Res \u00a027\n\u00a0: \u00a03527\u20133533","DOI":"10.1093\/nar\/27.17.3527"},{"key":"2021062515212428700_REF44","doi-asserted-by":"crossref","unstructured":"Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht \u00a0BD (2002) E2F integrates cell cycle progression with DNA repair, replication, and G(2)\/M checkpoints. Genes Dev \u00a016\n\u00a0: \u00a0245\u2013256","DOI":"10.1101\/gad.949802"},{"key":"2021062515212428700_REF45","doi-asserted-by":"crossref","unstructured":"Riou-Khamlichi C, Huntley R, Jacqmard A, Murray JA (1999) Cytokinin activation of Arabidopsis cell division through a D-type cyclin. Science \u00a0283\n\u00a0: \u00a01541\u20131544","DOI":"10.1126\/science.283.5407.1541"},{"key":"2021062515212428700_REF46","doi-asserted-by":"crossref","unstructured":"Rossignol P, Stevens R, Perennes C, Jasinki S, Cella R, Tremousaygue D, \u00a0Bergounioux C (2002) AtE2F-a and AtDP-a, members of the E2F family of transcription factors, induce Arabidopsis leaf cells to re-enter S phase. Mol Genet Genomics \u00a0266\n\u00a0: \u00a0995\u20131003","DOI":"10.1007\/s00438-001-0624-7"},{"key":"2021062515212428700_REF47","unstructured":"Sambrook J, Fritsch EF, and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY"},{"key":"2021062515212428700_REF48","doi-asserted-by":"crossref","unstructured":"Schnittger A, Schobinger U, Bouyer D, Weinl C, Stierhof YD, Hulskamp \u00a0M (2002a) Ectopic D-type cyclin expression induces not only DNA replication but also cell division in Arabidopsis trichomes. Proc Natl Acad Sci USA \u00a099\n\u00a0: \u00a06410\u20136415","DOI":"10.1073\/pnas.092657299"},{"key":"2021062515212428700_REF49","doi-asserted-by":"crossref","unstructured":"Schnittger A, Schobinger U, Stierhof YD, Hulskamp M (2002b) Ectopic B-type cyclin expression induces mitotic cycles in endoreduplicating Arabidopsis trichomes. Curr Biol \u00a012\n\u00a0: \u00a0415\u2013420","DOI":"10.1016\/S0960-9822(02)00693-0"},{"key":"2021062515212428700_REF50","doi-asserted-by":"crossref","unstructured":"Sekine M, Ito M, Uemukai K, Maeda Y, Nakagami H, Shinmyo A (1999) Isolation and characterization of the E2F-like gene in plants. FEBS Lett \u00a0460\n\u00a0: \u00a0117\u2013122","DOI":"10.1016\/S0014-5793(99)01296-X"},{"key":"2021062515212428700_REF51","doi-asserted-by":"crossref","unstructured":"Shan B, Lee WH (1994) Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol \u00a014\n\u00a0: \u00a08166\u20138173","DOI":"10.1128\/mcb.14.12.8166-8173.1994"},{"key":"2021062515212428700_REF52","doi-asserted-by":"crossref","unstructured":"Stevens R, Mariconti L, Rossignol P, Perennes C, Cella R, Bergounioux C (2002) Two E2F sites in the Arabidopsis MCM3 promoter have different roles in cell cycle activation and meristematic expression. J Biol Chem \u00a0277\n\u00a0: \u00a032978\u201332984","DOI":"10.1074\/jbc.M205125200"},{"key":"2021062515212428700_REF53","doi-asserted-by":"crossref","unstructured":"Trimarchi JM, Fairchild B, Wen J, Lees JA (2001) The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci USA \u00a098\n\u00a0: \u00a01519\u20131524","DOI":"10.1073\/pnas.98.4.1519"},{"key":"2021062515212428700_REF54","doi-asserted-by":"crossref","unstructured":"Vandepoele K, Raes J, De Veylder L, Rouze\u0301 P, Rombauts S, Inze\u0301 D (2002) Genome-wide analysis of core cell cycle genes in Arabidopsis. Plant Cell \u00a014\n\u00a0: \u00a0903\u2013916","DOI":"10.1105\/tpc.010445"},{"key":"2021062515212428700_REF55","doi-asserted-by":"crossref","unstructured":"von Arnim A, Stanley J (1992) Determinants of tomato golden mosaic virus symptom development located on DNA B. Virology \u00a0186\n\u00a0: \u00a0286\u2013293","DOI":"10.1016\/0042-6822(92)90083-2"},{"key":"2021062515212428700_REF56","doi-asserted-by":"crossref","unstructured":"Wang D, Russell JL, Johnson DG (2000) E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo. \u00a0Mol Cell Biol \u00a020\n\u00a0: \u00a03417\u20133424","DOI":"10.1128\/.20.10.3417-3424.2000"},{"key":"2021062515212428700_REF57","doi-asserted-by":"crossref","unstructured":"Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ (2002) Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev \u00a016\n\u00a0: \u00a0235\u2013244","DOI":"10.1101\/gad.943102"},{"key":"2021062515212428700_REF58","doi-asserted-by":"crossref","unstructured":"Wu L, Timmers C, Maiti B, Saavedra HI, Sang L, Chong GT, Nuckolls F, \u00a0Giangrande P, Wright FA, Field SJ et al. (2001) The E2F1\u20133 transcription factors are essential for cellular proliferation. Nature \u00a0414\n\u00a0: \u00a0457\u2013462","DOI":"10.1038\/35106593"},{"key":"2021062515212428700_REF59","doi-asserted-by":"crossref","unstructured":"Yagi H, Kato T, Nagata T, Habu T, Nozaki M, Matsushiro A, Nishimune \u00a0Y, Morita T (1995) Regulation of the mouse histone H2A: X gene promoter by the transcription factor E2F and CCAAT binding protein. J Biol Chem \u00a0270\n\u00a0: \u00a018759\u201318765","DOI":"10.1074\/jbc.270.32.18759"}],"container-title":["Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/plphys\/article-pdf\/132\/4\/2012\/38700183\/plphys_v132_4_2012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/plphys\/article-pdf\/132\/4\/2012\/38700183\/plphys_v132_4_2012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T15:23:00Z","timestamp":1624634580000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plphys\/article\/132\/4\/2012\/6111741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,1]]},"references-count":59,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,8,11]]},"published-print":{"date-parts":[[2003,8,1]]}},"URL":"https:\/\/doi.org\/10.1104\/pp.103.025080","relation":{},"ISSN":["1532-2548","0032-0889"],"issn-type":[{"value":"1532-2548","type":"electronic"},{"value":"0032-0889","type":"print"}],"subject":[],"published-other":{"date-parts":[[2003,8,1]]},"published":{"date-parts":[[2003,8,1]]}}}