{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:03:36Z","timestamp":1791230616621,"version":"4.1.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":3436,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mitogen-activated protein kinase (MAPK) cascades play important roles in disease resistance in model plant species such as Arabidopsis (Arabidopsis thaliana) and tobacco (Nicotiana tabacum). However, the importance of MAPK signaling pathways in the disease resistance of crops is still largely uninvestigated. To better understand the role of MAPK signaling pathways in disease resistance in soybean (Glycine max), 13, nine, and 10 genes encoding distinct MAPKs, MAPKKs, and MAPKKKs, respectively, were silenced using virus-induced gene silencing mediated by Bean pod mottle virus. Among the plants silenced for various MAPKs, MAPKKs, and MAPKKKs, those in which GmMAPK4 homologs (GmMPK4s) were silenced displayed strong phenotypes including stunted stature and spontaneous cell death on the leaves and stems, the characteristic hallmarks of activated defense responses. Microarray analysis showed that genes involved in defense responses, such as those in salicylic acid (SA) signaling pathways, were significantly up-regulated in GmMPK4-silenced plants, whereas genes involved in growth and development, such as those in auxin signaling pathways and in cell cycle and proliferation, were significantly down-regulated. As expected, SA and hydrogen peroxide accumulation was significantly increased in GmMPK4-silenced plants. Accordingly, GmMPK4-silenced plants were more resistant to downy mildew and Soybean mosaic virus compared with vector control plants. Using bimolecular fluorescence complementation analysis and in vitro kinase assays, we determined that GmMKK1 and GmMKK2 might function upstream of GmMPK4. Taken together, our results indicate that GmMPK4s negatively regulate SA accumulation and defense response but positively regulate plant growth and development, and their functions are conserved across plant species.<\/jats:p>","DOI":"10.1104\/pp.111.185686","type":"journal-article","created":{"date-parts":[[2011,8,31]],"date-time":"2011-08-31T01:49:07Z","timestamp":1314755347000},"page":"1363-1378","source":"Crossref","is-referenced-by-count":150,"title":["Soybean Homologs of MPK4 Negatively Regulate Defense Responses and Positively Regulate Growth and Development \u00a0 \u00a0"],"prefix":"10.1093","volume":"157","author":[{"given":"Jian-Zhong","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi D.","family":"Horstman","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duroy","family":"Navarre","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Li","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeunsook","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Nettleton","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Whitham","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology (J.-Z.L., H.D.H., E.B., C.Z., W.-L.Q., Y.L., J.H.H., S.A.W.), Department of Agronomy (M.A.G.), and Department of Statistics (D.N.), Iowa State University, Ames, Iowa 50011; Corn Insects and Crop Genetics Research Unit, United States Department of Agriculture-Agricultural Research Service, Ames, Iowa 50011 (M.A.G.); United States Department of Agriculture-Agricultural"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2011,8,30]]},"reference":[{"key":"2021052608282824400_b1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"2021052608282824400_b2","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1038\/sj.emboj.7600737","article-title":"The MAP kinase substrate MKS1 is a regulator of plant defense responses","volume":"24","author":"Andreasson","year":"2005","journal-title":"EMBO J"},{"key":"2021052608282824400_b3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.arplant.55.031903.141701","article-title":"Reactive oxygen species: metabolism, oxidative stress, and signal transduction","volume":"55","author":"Apel","year":"2004","journal-title":"Annu Rev Plant Biol"},{"key":"2021052608282824400_b4","doi-asserted-by":"crossref","first-page":"D115","DOI":"10.1093\/nar\/gkh131","article-title":"UniProt: the universal protein knowledgebase","volume":"32","author":"Apweiler","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2021052608282824400_b5","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/415977a","article-title":"MAP kinase signalling cascade in Arabidopsis innate immunity","volume":"415","author":"Asai","year":"2002","journal-title":"Nature"},{"key":"2021052608282824400_b6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene Ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"2021052608282824400_b7","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1469-8137.2010.03565.x","article-title":"Mitogen-activated protein kinase 4 is involved in the regulation of mitotic and cytokinetic microtubule transitions in Arabidopsis thaliana","volume":"189","author":"Beck","year":"2011","journal-title":"New Phytol"},{"key":"2021052608282824400_b8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc B"},{"key":"2021052608282824400_b9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-313X.2006.02806.x","article-title":"Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid\/ethylene-dependent responses via EDS1 and PAD4","volume":"47","author":"Brodersen","year":"2006","journal-title":"Plant J"},{"key":"2021052608282824400_b10","doi-asserted-by":"crossref","first-page":"20131","DOI":"10.1073\/pnas.0704901104","article-title":"Pseudomonas syringae type III effector AvrRpt2 alters Arabidopsis thaliana auxin physiology","volume":"104","author":"Chen","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021052608282824400_b11","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1073\/pnas.88.18.8179","article-title":"Identification of a soluble salicylic acid-binding protein that may function in signal transduction in the plant disease-resistance response","volume":"88","author":"Chen","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021052608282824400_b12","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0167-4781(02)00298-1","article-title":"Leucine zipper-containing WRKY proteins widen the spectrum of immediate early elicitor-induced WRKY transcription factors in parsley","volume":"1576","author":"Cormack","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"2021052608282824400_b13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/29087","article-title":"Nitric oxide functions as a signal in plant disease resistance","volume":"394","author":"Delledonne","year":"1998","journal-title":"Nature"},{"key":"2021052608282824400_b14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0092-8674(00)81911-X","article-title":"A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death","volume":"88","author":"Dietrich","year":"1997","journal-title":"Cell"},{"key":"2021052608282824400_b15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1020780022549","article-title":"Expression profiles of the Arabidopsis WRKY gene superfamily during plant defense response","volume":"51","author":"Dong","year":"2003","journal-title":"Plant Mol Biol"},{"key":"2021052608282824400_b16","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/bioinformatics\/btg165","article-title":"Noise sampling method: an ANOVA approach allowing robust selection of differentially regulated genes measured by DNA microarrays","volume":"19","author":"Draghici","year":"2003","journal-title":"Bioinformatics"},{"key":"2021052608282824400_b17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.phyto.42.040803.140421","article-title":"Systemic acquired resistance","volume":"42","author":"Durrant","year":"2004","journal-title":"Annu Rev Phytopathol"},{"key":"2021052608282824400_b18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"2021052608282824400_b19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1360-1385(00)01600-9","article-title":"The WRKY superfamily of plant transcription factors","volume":"5","author":"Eulgem","year":"2000","journal-title":"Trends Plant Sci"},{"key":"2021052608282824400_b20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.pbi.2007.04.020","article-title":"Networks of WRKY transcription factors in defense signaling","volume":"10","author":"Eulgem","year":"2007","journal-title":"Curr Opin Plant Biol"},{"key":"2021052608282824400_b21","article-title":"The Design of Experiments, Ed 8","author":"Fisher","year":"1966"},{"key":"2021052608282824400_b22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1094\/MPMI-22-1-0086","article-title":"GmRAR1 and GmSGT1 are required for basal, R gene-mediated and systemic acquired resistance in soybean","volume":"22","author":"Fu","year":"2009","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b23","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/cr.2008.300","article-title":"MEKK1, MKK1\/MKK2 and MPK4 function together in a mitogen-activated protein kinase cascade to regulate innate immunity in plants","volume":"18","author":"Gao","year":"2008","journal-title":"Cell Res"},{"key":"2021052608282824400_b24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/bioinformatics\/btg405","article-title":"affy: analysis of Affymetrix GeneChip data at the probe level","volume":"20","author":"Gautier","year":"2004","journal-title":"Bioinformatics"},{"key":"2021052608282824400_b25","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1093\/pcp\/pci211","article-title":"A mitogen-activated protein kinase NtMPK4 activated by SIPKK is required for jasmonic acid signaling and involved in ozone tolerance via stomatal movement in tobacco","volume":"46","author":"Gomi","year":"2005","journal-title":"Plant Cell Physiol"},{"key":"2021052608282824400_b26","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1094\/MPMI-05-10-0121","article-title":"Intracellular transport of viruses and their components: utilizing the cytoskeleton and membrane highways","volume":"23","author":"Harries","year":"2010","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b27","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1094\/Phyto-74-1370","article-title":"Relationship between heat-induced fungal death and plant necrosis in compatible and incompatible interactions involving the bean and cowpea rust fungi","volume":"74","author":"Heath","year":"1984","journal-title":"Phytopathology"},{"key":"2021052608282824400_b28","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1094\/Phyto-86-704","article-title":"Applications of KOH-aniline blue fluorescence in the study of plant-fungal interactions","volume":"86","author":"Hood","year":"1996","journal-title":"Phytopathology"},{"key":"2021052608282824400_b29","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1104\/pp.110.157370","article-title":"Functional analysis of the Arabidopsis PAL gene family in plant growth, development, and response to environmental stress","volume":"153","author":"Huang","year":"2010","journal-title":"Plant Physiol"},{"key":"2021052608282824400_b30","doi-asserted-by":"crossref","first-page":"36969","DOI":"10.1074\/jbc.M605319200","article-title":"MEKK1 is required for MPK4 activation and regulates tissue-specific and temperature-dependent cell death in Arabidopsis","volume":"281","author":"Ichimura","year":"2006","journal-title":"J Biol Chem"},{"key":"2021052608282824400_b31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S1360-1385(02)02302-6","article-title":"Mitogen-activated protein kinase cascades in plants: a new nomenclature","volume":"7","author":"Ichimura","year":"2002","journal-title":"Trends Plant Sci"},{"key":"2021052608282824400_b32","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1360-1385(01)02058-1","article-title":"Mapping out the roles of MAP kinases in plant defense","volume":"6","author":"Innes","year":"2001","journal-title":"Trends Plant Sci"},{"key":"2021052608282824400_b33","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1002","article-title":"Use of mixture models in a microarray-based screening procedure for detecting differentially represented yeast mutants","volume":"2","author":"Irizarry","year":"2003","journal-title":"Stat Appl Genet Mol Biol"},{"key":"2021052608282824400_b34","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/342837a0","article-title":"The GUS reporter gene system","volume":"342","author":"Jefferson","year":"1989","journal-title":"Nature"},{"key":"2021052608282824400_b35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature05286","article-title":"The plant immune system","volume":"444","author":"Jones","year":"2006","journal-title":"Nature"},{"key":"2021052608282824400_b36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S1360-1385(02)02251-3","article-title":"Gateway vectors for Agrobacterium-mediated plant transformation","volume":"7","author":"Karimi","year":"2002","journal-title":"Trends Plant Sci"},{"key":"2021052608282824400_b37","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-313X.2010.04264.x","article-title":"A rice fungal MAMP-responsive MAPK cascade regulates metabolic flow to antimicrobial metabolite synthesis","volume":"63","author":"Kishi-Kaboshi","year":"2010","journal-title":"Plant J"},{"key":"2021052608282824400_b38","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1105\/tpc.110.077164","article-title":"The MAP kinase MPK4 is required for cytokinesis in Arabidopsis thaliana","volume":"22","author":"Kosetsu","year":"2010","journal-title":"Plant Cell"},{"key":"2021052608282824400_b39","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1073\/pnas.97.6.2940","article-title":"Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants","volume":"97","author":"Kovtun","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021052608282824400_b40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.arplant.48.1.251","article-title":"The oxidative burst in plant disease resistance","volume":"48","author":"Lamb","year":"1997","journal-title":"Annu Rev Plant Physiol Plant Mol Biol"},{"key":"2021052608282824400_b41","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4161\/psb.3.12.6848","article-title":"Comprehensive analysis of protein-protein interactions between Arabidopsis MAPKs and MAPK kinases helps define potential MAPK signalling modules","volume":"3","author":"Lee","year":"2008","journal-title":"Plant Signal Behav"},{"key":"2021052608282824400_b42","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1104\/pp.105.065722","article-title":"The tobacco mosaic virus 126-kilodalton protein, a constituent of the virus replication complex, alone or within the complex aligns with and traffics along microfilaments","volume":"138","author":"Liu","year":"2005","journal-title":"Plant Physiol"},{"key":"2021052608282824400_b43","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1105\/tpc.111.084996","article-title":"Phosphorylation of a WRKY transcription factor by two pathogen-responsive MAPKs drives phytoalexin biosynthesis in Arabidopsis","volume":"23","author":"Mao","year":"2011","journal-title":"Plant Cell"},{"key":"2021052608282824400_b44","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1094\/MPMI-18-1027","article-title":"Tobacco transcription factor WRKY1 is phosphorylated by the MAP kinase SIPK and mediates HR-like cell death in tobacco","volume":"18","author":"Menke","year":"2005","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b45","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-313X.2006.02888.x","article-title":"The Arabidopsis MAP kinase kinase MKK1 participates in defence responses to the bacterial elicitor flagellin","volume":"48","author":"M\u00e9sz\u00e1ros","year":"2006","journal-title":"Plant J"},{"key":"2021052608282824400_b46","doi-asserted-by":"crossref","first-page":"38697","DOI":"10.1074\/jbc.M605293200","article-title":"A mitogen-activated protein kinase kinase kinase mediates reactive oxygen species homeostasis in Arabidopsis","volume":"281","author":"Nakagami","year":"2006","journal-title":"J Biol Chem"},{"key":"2021052608282824400_b47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00709-010-0246-1","article-title":"Cellular pathways for viral transport through plasmodesmata","volume":"248","author":"Niehl","year":"2011","journal-title":"Protoplasma"},{"key":"2021052608282824400_b48","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1007\/s00425-007-0556-5","article-title":"The isochorismate pathway is negatively regulated by salicylic acid signaling in O3-exposed Arabidopsis","volume":"226","author":"Ogawa","year":"2007","journal-title":"Planta"},{"key":"2021052608282824400_b49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1094\/MPMI-08-10-0187","article-title":"Functional analysis of the Asian soybean rust resistance pathway mediated by Rpp2","volume":"24","author":"Pandey","year":"2011","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b50","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.pbi.2005.07.006","article-title":"Role of mitogen-activated protein kinases in plant immunity","volume":"8","author":"Pedley","year":"2005","journal-title":"Curr Opin Plant Biol"},{"key":"2021052608282824400_b51","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0092-8674(00)00213-0","article-title":"Arabidopsis map kinase 4 negatively regulates systemic acquired resistance","volume":"103","author":"Petersen","year":"2000","journal-title":"Cell"},{"key":"2021052608282824400_b52","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/mp\/ssn079","article-title":"A major role of the MEKK1-MKK1\/2-MPK4 pathway in ROS signalling","volume":"2","author":"Pitzschke","year":"2009","journal-title":"Mol Plant"},{"key":"2021052608282824400_b53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pbi.2009.06.008","article-title":"MAPK cascade signalling networks in plant defence","volume":"12","author":"Pitzschke","year":"2009","journal-title":"Curr Opin Plant Biol"},{"key":"2021052608282824400_b54","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1038\/emboj.2008.147","article-title":"Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus","volume":"27","author":"Qiu","year":"2008","journal-title":"EMBO J"},{"key":"2021052608282824400_b55","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1104\/pp.108.120006","article-title":"Arabidopsis mitogen-activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1","volume":"148","author":"Qiu","year":"2008","journal-title":"Plant Physiol"},{"key":"2021052608282824400_b56","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1073\/pnas.0711301105","article-title":"A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis","volume":"105","author":"Ren","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021052608282824400_b57","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1074\/jbc.M109495200","article-title":"Cell death mediated by MAPK is associated with hydrogen peroxide production in Arabidopsis","volume":"277","author":"Ren","year":"2002","journal-title":"J Biol Chem"},{"key":"2021052608282824400_b58","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1104\/pp.104.042663","article-title":"Oxidative stress-induced calcium signaling in Arabidopsis","volume":"135","author":"Rentel","year":"2004","journal-title":"Plant Physiol"},{"key":"2021052608282824400_b59","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1104\/pp.118.2.565","article-title":"Intermediates of salicylic acid biosynthesis in tobacco","volume":"118","author":"Ribnicky","year":"1998","journal-title":"Plant Physiol"},{"key":"2021052608282824400_b60","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.tplants.2010.02.006","article-title":"WRKY transcription factors","volume":"15","author":"Rushton","year":"2010","journal-title":"Trends Plant Sci"},{"key":"2021052608282824400_b61","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1471-2229-9-105","article-title":"Systemic acquired resistance in soybean is regulated by two proteins, orthologous to Arabidopsis NPR1","volume":"9","author":"Sandhu","year":"2009","journal-title":"BMC Plant Biol"},{"key":"2021052608282824400_b62","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature08670","article-title":"Genome sequence of the palaeopolyploid soybean","volume":"463","author":"Schmutz","year":"2010","journal-title":"Nature"},{"key":"2021052608282824400_b63","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1105\/tpc.106.049585","article-title":"The PP2C-type phosphatase AP2C1, which negatively regulates MPK4 and MPK6, modulates innate immunity, jasmonic acid, and ethylene levels in Arabidopsis","volume":"19","author":"Schweighofer","year":"2007","journal-title":"Plant Cell"},{"key":"2021052608282824400_b64","first-page":"86","article-title":"Opposite functions of a rice mitogen-activated protein kinase during the process of resistance against Xanthomonas oryzae","volume":"64","author":"Shen","year":"2010","journal-title":"Plant J"},{"key":"2021052608282824400_b65","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1027","article-title":"Linear models and empirical Bayes methods for assessing differential expression in microarray experiments","volume":"3","author":"Smyth","year":"2004","journal-title":"Stat Appl Genet Mol Biol"},{"key":"2021052608282824400_b66","doi-asserted-by":"crossref","DOI":"10.1007\/0-387-29362-0_23","article-title":"Limma: Linear Models for Microarray Data","author":"Smyth","year":"2005"},{"key":"2021052608282824400_b67","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1104\/pp.106.091389","article-title":"MEKK1 is required for flg22-induced MPK4 activation in Arabidopsis plants","volume":"143","author":"Suarez-Rodriguez","year":"2007","journal-title":"Plant Physiol"},{"key":"2021052608282824400_b68","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1105\/tpc.106.046581","article-title":"The mitogen-activated protein kinase cascade MKK3-MPK6 is an important part of the jasmonate signal transduction pathway in Arabidopsis","volume":"19","author":"Takahashi","year":"2007","journal-title":"Plant Cell"},{"key":"2021052608282824400_b69","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1073\/pnas.1132113100","article-title":"Conservation and molecular dissection of ROUGH SHEATH2 and ASYMMETRIC LEAVES1 function in leaf development","volume":"100","author":"Theodoris","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021052608282824400_b70","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1111\/j.1365-313X.2004.02016.x","article-title":"MAPMAN: a user-driven tool to display genomics data sets onto diagrams of metabolic pathways and other biological processes","volume":"37","author":"Thimm","year":"2004","journal-title":"Plant J"},{"key":"2021052608282824400_b71","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1046\/j.1365-313X.1997.11061187.x","article-title":"Subcellular localization of H2O2 in plants: H2O2 accumulation in papillae and hypersensitive response during the barley-powdery mildew interaction","volume":"11","author":"Thordal-Christensen","year":"1997","journal-title":"Plant J"},{"key":"2021052608282824400_b72","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1094\/MPMI-20-8-0887","article-title":"Distinct biphasic mRNA changes in response to Asian soybean rust infection","volume":"20","author":"van de Mortel","year":"2007","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b73","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1471-2229-11-89","article-title":"WRKY transcription factors involved in activation of SA biosynthesis genes","volume":"11","author":"van Verk","year":"2011","journal-title":"BMC Plant Biol"},{"key":"2021052608282824400_b74","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-313X.2004.02219.x","article-title":"Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation","volume":"40","author":"Walter","year":"2004","journal-title":"Plant J"},{"key":"2021052608282824400_b75","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.cub.2007.09.025","article-title":"Salicylic acid inhibits pathogen growth in plants through repression of the auxin signaling pathway","volume":"17","author":"Wang","year":"2007","journal-title":"Curr Biol"},{"key":"2021052608282824400_b76","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1094\/MPMI-19-0304","article-title":"Pseudomonas syringae effector avrB confers soybean cultivar-specific avirulence on Soybean mosaic virus adapted for transgene expression but effector avrPto does not","volume":"19","author":"Wang","year":"2006","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b77","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1094\/MPMI-22-3-0235","article-title":"Overexpression of Brassica napus MPK4 enhances resistance to Sclerotinia sclerotiorum in oilseed rape","volume":"22","author":"Wang","year":"2009","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b78","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/35107108","article-title":"Isochorismate synthase is required to synthesize salicylic acid for plant defence","volume":"414","author":"Wildermuth","year":"2001","journal-title":"Nature"},{"key":"2021052608282824400_b79","first-page":"347","article-title":"BarleyBase\/PLEXdb","volume":"406","author":"Wise","year":"2007","journal-title":"Methods Mol Biol"},{"key":"2021052608282824400_b80","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1104\/pp.107.100800","article-title":"The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death","volume":"145","author":"Yang","year":"2007","journal-title":"Plant Physiol"},{"key":"2021052608282824400_b81","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1105\/tpc.020479","article-title":"A haplotype-specific Resistance gene regulated by BONZAI1 mediates temperature-dependent growth control in Arabidopsis","volume":"16","author":"Yang","year":"2004","journal-title":"Plant Cell"},{"key":"2021052608282824400_b82","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1105\/tpc.008680","article-title":"Nicotiana benthamiana gp91phox homologs NbrbohA and NbrbohB participate in H2O2 accumulation and resistance to Phytophthora infestans","volume":"15","author":"Yoshioka","year":"2003","journal-title":"Plant Cell"},{"key":"2021052608282824400_b83","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1105\/TPC.010115","article-title":"Evidence for an important role of WRKY DNA binding proteins in the regulation of NPR1 gene expression","volume":"13","author":"Yu","year":"2001","journal-title":"Plant Cell"},{"key":"2021052608282824400_b84","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/j.1365-313X.2011.04642.x","article-title":"AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis","volume":"67","author":"Zeng","year":"2011","journal-title":"Plant J"},{"key":"2021052608282824400_b85","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1094\/MPMI-22-2-0123","article-title":"Development and use of an efficient DNA-based viral gene silencing vector for soybean","volume":"22","author":"Zhang","year":"2009","journal-title":"Mol Plant Microbe Interact"},{"key":"2021052608282824400_b86","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1104\/pp.109.151639","article-title":"The development of an efficient multipurpose bean pod mottle virus viral vector set for foreign gene expression and RNA silencing","volume":"153","author":"Zhang","year":"2010","journal-title":"Plant Physiol"}],"container-title":["Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/plphys\/article-pdf\/157\/3\/1363\/38111009\/plphys_v157_3_1363.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/plphys\/article-pdf\/157\/3\/1363\/38111009\/plphys_v157_3_1363.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T12:35:29Z","timestamp":1741523729000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plphys\/article\/157\/3\/1363\/6109024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,30]]},"references-count":86,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,8,30]]},"published-print":{"date-parts":[[2011,11,3]]}},"URL":"https:\/\/doi.org\/10.1104\/pp.111.185686","relation":{},"ISSN":["1532-2548"],"issn-type":[{"value":"1532-2548","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2011,11,1]]},"published":{"date-parts":[[2011,8,30]]}}}