{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:30:45Z","timestamp":1792182645123,"version":"4.4.0"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":3058,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Plant resistance to phytopathogenic microorganisms mainly relies on the activation of an innate immune response usually launched after recognition by the plant cells of microbe-associated molecular patterns. The plant hormones, salicylic acid (SA), jasmonic acid, and ethylene have emerged as key players in the signaling networks involved in plant immunity. Rhamnolipids (RLs) are glycolipids produced by bacteria and are involved in surface motility and biofilm development. Here we report that RLs trigger an immune response in Arabidopsis (Arabidopsis thaliana) characterized by signaling molecules accumulation and defense gene activation. This immune response participates to resistance against the hemibiotrophic bacterium Pseudomonas syringae pv tomato, the biotrophic oomycete Hyaloperonospora arabidopsidis, and the necrotrophic fungus Botrytis cinerea. We show that RL-mediated resistance involves different signaling pathways that depend on the type of pathogen. Ethylene is involved in RL-induced resistance to H. arabidopsidis and to P. syringae pv tomato whereas jasmonic acid is essential for the resistance to B. cinerea. SA participates to the restriction of all pathogens. We also show evidence that SA-dependent plant defenses are potentiated by RLs following challenge by B. cinerea or P. syringae pv tomato. These results highlight a central role for SA in RL-mediated resistance. In addition to the activation of plant defense responses, antimicrobial properties of RLs are thought to participate in the protection against the fungus and the oomycete. Our data highlight the intricate mechanisms involved in plant protection triggered by a new type of molecule that can be perceived by plant cells and that can also act directly onto pathogens.<\/jats:p>","DOI":"10.1104\/pp.112.201913","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T05:31:38Z","timestamp":1347427898000},"page":"1630-1641","source":"Crossref","is-referenced-by-count":159,"title":["Rhamnolipids Elicit Defense Responses and Induce Disease Resistance against Biotrophic, Hemibiotrophic, and Necrotrophic Pathogens That Require Different Signaling Pathways in Arabidopsis and Highlight a Central Role for Salicylic Acid\n\u00a0\n\u00a0\n\u00a0"],"prefix":"10.1093","volume":"160","author":[{"given":"Lisa","family":"Sanchez","sequence":"first","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Courteaux","sequence":"additional","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Hubert","sequence":"additional","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Kauffmann","sequence":"additional","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Hugues","family":"Renault","sequence":"additional","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Baillieul","sequence":"additional","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phan","family":"Dorey","sequence":"additional","affiliation":[{"name":"Laboratoire de Stress, D\u00e9fenses, et Reproduction des Plantes, L'Unit\u00e9 de Recherche Vignes et Vins de Champagne, Equipe d'Accueil 4707 (L.S., B.C., C.C., F.B., S.D.) and Institut de Chimie Mol\u00e9culaire de Reims Unit\u00e9 Mixte de Recherche, Centre National de la Recherche Scientifique 6229, Institut F\u00e9d\u00e9ratif Recherche 53 (J.H., J.-H.R.), Universit\u00e9 de Reims Champagne-Ardenne, F-51687 Reims cedex 2, Fr"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"2021041917530885900_b1","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00253-010-2498-2","article-title":"Rhamnolipids: diversity of structures, microbial origins and roles","volume":"86","author":"Abdel-Mawgoud","year":"2010","journal-title":"Appl Microbiol Biotechnol"},{"key":"2021041917530885900_b2","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1515\/BC.2006.040","article-title":"Endotoxin-like properties of a rhamnolipid exotoxin from Burkholderia (Pseudomonas) plantarii: immune cell stimulation and biophysical characterization","volume":"387","author":"Andr\u00e4","year":"2006","journal-title":"Biol Chem"},{"key":"2021041917530885900_b3","first-page":"1823","article-title":"Fumonisin B1-induced cell death in Arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways","volume":"12","author":"Asai","year":"2000","journal-title":"Plant Cell"},{"key":"2021041917530885900_b4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1104\/pp.012658","article-title":"Molecular cloning and biological activity of \u03b1-, \u03b2-, and \u03b3-megaspermin, three elicitins secreted by Phytophthora megasperma H20","volume":"131","author":"Baillieul","year":"2003","journal-title":"Plant Physiol"},{"key":"2021041917530885900_b5","doi-asserted-by":"crossref","first-page":"7116","DOI":"10.1002\/chem.200600482","article-title":"Chemical synthesis of a glycolipid library by a solid-phase strategy allows elucidation of the structural 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induce systemic acquired resistance (SAR)","volume":"48","author":"Govrin","year":"2002","journal-title":"Plant Mol Biol"},{"key":"2021041917530885900_b30","first-page":"513","article-title":"Exploiting the triple response of Arabidopsis to identify ethylene-related mutants","volume":"2","author":"Guzm\u00e1n","year":"1990","journal-title":"Plant Cell"},{"key":"2021041917530885900_b31","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-313X.2008.03688.x","article-title":"PAMP-induced defense responses in potato require both salicylic acid and jasmonic acid","volume":"57","author":"Halim","year":"2009","journal-title":"Plant J"},{"key":"2021041917530885900_b32","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1046\/j.1365-313X.2003.01881.x","article-title":"Genetic evidence that expression of NahG modifies defence pathways independent of salicylic acid biosynthesis in the Arabidopsis-Pseudomonas syringae pv. tomato 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