{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:20:35Z","timestamp":1784067635454,"version":"3.55.0"},"reference-count":89,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":3020,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Low Chlorophyll Accumulation A (LCAA) antisense plants were obtained from a screen for genes whose partial down-regulation results in a strong chlorophyll deficiency in tobacco (Nicotiana tabacum). The LCAA mutants are affected in a plastid-localized protein of unknown function, which is conserved in cyanobacteria and all photosynthetic eukaryotes. They suffer from drastically reduced light-harvesting complex (LHC) contents, while the accumulation of all other photosynthetic complexes per leaf area is less affected. As the disturbed accumulation of LHC proteins could be either attributable to a defect in LHC biogenesis itself or to a bottleneck in chlorophyll biosynthesis, chlorophyll synthesis rates and chlorophyll synthesis intermediates were measured. LCAA antisense plants accumulate magnesium (Mg) protoporphyrin monomethylester and contain reduced protochlorophyllide levels and a reduced content of CHL27, a subunit of the Mg protoporphyrin monomethylester cyclase. Bimolecular fluorescence complementation assays confirm a direct interaction between LCAA and CHL27. 5-Aminolevulinic acid synthesis rates are increased and correlate with an increased content of glutamyl-transfer RNA reductase. We suggest that LCAA encodes an additional subunit of the Mg protoporphyrin monomethylester cyclase, is required for the stability of CHL27, and contributes to feedback-control of 5-aminolevulinic acid biosynthesis, the rate-limiting step of chlorophyll biosynthesis.<\/jats:p>","DOI":"10.1104\/pp.112.206045","type":"journal-article","created":{"date-parts":[[2012,10,20]],"date-time":"2012-10-20T02:46:20Z","timestamp":1350701180000},"page":"1923-1939","source":"Crossref","is-referenced-by-count":52,"title":["LCAA, a Novel Factor Required for Magnesium Protoporphyrin Monomethylester Cyclase Accumulation and Feedback Control of Aminolevulinic Acid Biosynthesis in Tobacco\n\u00a0\n\u00a0"],"prefix":"10.1093","volume":"160","author":[{"given":"Christin Anne","family":"Albus","sequence":"first","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute 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B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Kahlau","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute of Biology, Humboldt University Berlin, D\u201310115 Berlin, Germany (A.S., O.C., M.R., B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxi","family":"Rothbart","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute of Biology, Humboldt University Berlin, D\u201310115 Berlin, Germany (A.S., O.C., M.R., B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram","family":"Thiele","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute of Biology, Humboldt University Berlin, D\u201310115 Berlin, Germany (A.S., O.C., M.R., B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Lein","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute of Biology, Humboldt University Berlin, D\u201310115 Berlin, Germany (A.S., O.C., M.R., B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Bock","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute of Biology, Humboldt University Berlin, D\u201310115 Berlin, Germany (A.S., O.C., M.R., B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Grimm","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute of Biology, Humboldt University Berlin, D\u201310115 Berlin, Germany (A.S., O.C., M.R., B.G.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Aurel","family":"Sch\u00f6ttler","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut f\u00fcr Molekulare Pflanzenphysiologie, D\u201314476 Potsdam-Golm, Germany (C.A.A., S.K., W.T., W.L., R.B., M.A.S.); and Plant Physiology Group, Institute of Biology, Humboldt University Berlin, D\u201310115 Berlin, Germany (A.S., O.C., M.R., 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