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Chemical weed control began over a century ago with inorganic compounds and transitioned to the age of organic herbicides. Targeted herbicide research has created a steady stream of successful products. However, safeners have proven to be more difficult to find. Once found, the mode of action of the safener must be determined, partly to help in the discovery of further compounds within the same class. However, mounting regulatory and economic pressure has changed the industry completely, making it harder to find a successful herbicide. Herbicide resistance has also become a major problem, increasing the difficulty of controlling weeds. As a result, the development of new molecules has become a rare event today.<\/jats:p>","DOI":"10.1104\/pp.114.241901","type":"journal-article","created":{"date-parts":[[2014,8,8]],"date-time":"2014-08-08T04:06:44Z","timestamp":1407470804000},"page":"1119-1131","source":"Crossref","is-referenced-by-count":234,"title":["Herbicides as Weed Control Agents: State of the Art: I. 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