{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:02:01Z","timestamp":1791086521359,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Plant accumulation of Fe and other metals can be enhanced under Fe deficiency. We investigated the influence of Fe status on heavy-metal and divalent-cation uptake in roots of pea (Pisum sativum L. cv Sparkle) seedlings using Cd2+ uptake as a model system. Radiotracer techniques were used to quantify unidirectional 109Cd influx into roots of Fe-deficient and Fe-sufficient pea seedlings. The concentration-dependent kinetics for 109Cd influx were graphically complex and nonsaturating but could be resolved into a linear component and a saturable component exhibiting Michaelis-Menten kinetics. We demonstrated that the linear component was apoplastically bound Cd2+ remaining in the root cell wall after desorption, whereas the saturable component was transporter-mediated Cd2+ influx across the root-cell plasma membrane. The Cd2+ transport system in roots of both Fe-deficient and Fe-sufficient seedlings exhibited similar Michaelis constant values, 1.5 and 0.6 \u03bcm, respectively, for saturable Cd2+ influx, whereas the maximum initial velocity for Cd2+ uptake in Fe-deficient seedlings was nearly 7-fold higher than that in Fe-grown seedlings. Investigations into the mechanistic basis for this response demonstrated that Fe-deficiency-induced stimulation of the plasma membrane H+-ATPase did not play a role in the enhanced Cd2+ uptake. Expression studies with the Fe2+transporter cloned from Arabidopsis, IRT1, indicated that Fe deficiency induced the expression of this transporter, which might facilitate the transport of heavy-metal divalent cations such as Cd2+ and Zn2+, in addition to Fe2+.<\/jats:p>","DOI":"10.1104\/pp.116.3.1063","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:00:20Z","timestamp":1027746020000},"page":"1063-1072","source":"Crossref","is-referenced-by-count":346,"title":["The Role of Iron-Deficiency Stress Responses in Stimulating Heavy-Metal Transport in Plants1"],"prefix":"10.1093","volume":"116","author":[{"given":"Clara K.","family":"Cohen","sequence":"first","affiliation":[{"name":"United States Plant, Soil, and Nutrition Laboratory, United States Department of Agriculture-Agricultural Research Service, Cornell University, Ithaca, New York 14853 (C.K.C., D.F.G., L.V.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tama C.","family":"Fox","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755 (T.C.F.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Garvin","sequence":"additional","affiliation":[{"name":"United States Plant, Soil, and Nutrition Laboratory, United States Department of Agriculture-Agricultural Research Service, Cornell University, Ithaca, New York 14853 (C.K.C., D.F.G., L.V.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon V.","family":"Kochian","sequence":"additional","affiliation":[{"name":"United States Plant, Soil, and Nutrition Laboratory, United States Department of Agriculture-Agricultural Research Service, Cornell University, Ithaca, New York 14853 (C.K.C., D.F.G., L.V.K.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1998,3,1]]},"reference":[{"key":"2021050309433345300_R1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2134\/agronj1971.00021962006300010029x","article-title":"Sites of iron reduction in soybean plants.","volume":"63","author":"Ambler","year":"1971","journal-title":"Agron J"},{"key":"2021050309433345300_R2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0092-8674(94)90346-8","article-title":"The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.","volume":"76","author":"Askwith","year":"1994","journal-title":"Cell"},{"key":"2021050309433345300_R3","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.1073\/pnas.87.20.7824","article-title":"Cation-selective channels in the vacuolar membrane of Saccharomyces: dependence on calcium, redox state, and 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