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Specifically, we found that the respiration of AS8 cells was restricted during P-limited growth, when the potential for severe adenylate control of respiration (at the level of C supply to the mitochondrion and\/or at the level of oxidative phosphorylation) is high due to the low cellular levels of ADP and\/or inorganic P. As a result of this respiratory restriction, AS8 cells had altered growth, morphology, cellular composition, and patterns of respiratory C flow to amino acid synthesis compared with wild-type cells with abundant AOX protein. Also, AS8 cells under P limitation displayed high in vivo rates of generation of active oxygen species compared with wild-type cells. This difference could be abolished by an uncoupler of mitochondrial oxidative phosphorylation. Our results suggest that induction of non-phosphorylating AOX respiration (like induction of adenylate and inorganic P-independent pathways in glycolysis) is an important plant metabolic adaptation to P limitation. By preventing severe respiratory restriction, AOX acts to prevent both redirections in C metabolism and the excessive generation of harmful active oxygen species in the mitochondrion.<\/jats:p>","DOI":"10.1104\/pp.121.4.1309","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:01:20Z","timestamp":1027746080000},"page":"1309-1320","source":"Crossref","is-referenced-by-count":122,"title":["Increased Respiratory Restriction during Phosphate-Limited Growth in Transgenic Tobacco Cells Lacking Alternative Oxidase"],"prefix":"10.1093","volume":"121","author":[{"given":"Hannah L.","family":"Parsons","sequence":"first","affiliation":[{"name":"Division of Life Science and Department of Botany, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine Y.H.","family":"Yip","sequence":"additional","affiliation":[{"name":"Division of Life Science and 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