{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:15:52Z","timestamp":1784718952531,"version":"3.55.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Salicylates, the main phenolic glucosides of northern willow (Salix spp.), play an important role in plant-herbivore interactions. Salicylates are labile metabolites that are thought to undergo metabolic turnover. Salicylates are synthesized from phenylalanine (Phe) via the shikimate pathway. 2-Aminoindan-2-phosphonic acid (AIP), a strong inhibitor of Phe ammonia-lyase (EC 4.3.1.5), was used to block the biosynthesis of salicylates. The aim of this study was to investigate long-term turnover of salicylates in intact micropropagated plantlets of Salix myrsinifolia Salisb. The biosynthesis of salicylates was inhibited efficiently but not completely by 30 \u03bcm 2-aminoindan-2-phosphonic acid. Inhibitor treatment, aside from leading to a high accumulation of Phe, also led to an increase in tyrosine and tryptophan, indicating that 2-aminoindan-2-phosphonic acid may also inhibit enzymes other than Phe ammonia-lyase. Salicylates were shown to be unexpectedly stable metabolites that did not undergo marked metabolic turnover in intact plants; in leaves no significant turnover occurred, and in the stems the five salicylates studied were turned over slowly, with half-lives of 11 to 25 d. The total amount of salicylate in mature shoots decreased only 0.6% per day.<\/jats:p>","DOI":"10.1104\/pp.122.3.895","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:01:20Z","timestamp":1027746080000},"page":"895-906","source":"Crossref","is-referenced-by-count":50,"title":["Salicylates of Intact <i>Salix myrsinifolia<\/i> Plantlets Do Not Undergo Rapid Metabolic Turnover"],"prefix":"10.1093","volume":"122","author":[{"given":"Teija Marjaana","family":"Ruuhola","sequence":"first","affiliation":[{"name":"Department of Biology, University of Joensuu, Box 111, FIN\u201380101 Joensuu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maija-Riitta Kristiina","family":"Julkunen-Tiitto","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Joensuu, Box 111, FIN\u201380101 Joensuu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,3,1]]},"reference":[{"key":"2021062510385148200_R1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1104\/pp.94.3.1219","article-title":"Turnover of dhurrin in green sorghum seedlings.","volume":"94","author":"Adewusi","year":"1990","journal-title":"Plant Physiol"},{"key":"2021062510385148200_R2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF00424506","article-title":"Turnover of isoflavones in Cicer arietinum L.","volume":"67","author":"Amrhein","year":"1980","journal-title":"Naturwissenschaften"},{"key":"2021062510385148200_R3","first-page":"139","article-title":"Inhibition of lignin formation by l-\u03b1-aminooxy-\u03b2-phenylpropionic acid, an inhibitor of phenylalanine ammonia-lyase.","volume":"29","author":"Amrhein","year":"1983","journal-title":"Eur J Cell Biol"},{"key":"2021062510385148200_R4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00391582","article-title":"Inhibition of anthocyanin formation in seedlings and flowers by the enantiomers of l-\u03b1-aminooxy-\u03b2-phenylpropionic acid and their N-benzyloxycarbonyl dervivatives.","volume":"144","author":"Amrhein","year":"1979","journal-title":"Planta"},{"key":"2021062510385148200_R5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2307\/3544308","article-title":"Carbon\/nutrient balance of boreal plants in relation to vertebrate herbivory.","volume":"40","author":"Bryant","year":"1983","journal-title":"Oikos"},{"key":"2021062510385148200_R6","first-page":"343","article-title":"Woody plant-mammal interactions.","volume":"2","author":"Bryant","year":"1992","journal-title":"Herbivores: Their Interactions with Secondary Metabolites"},{"key":"2021062510385148200_R7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF00446375","article-title":"Plant tyrosine decarboxylase can be strongly inhibited by l-\u03b1-aminooxy-\u03b2-phenylpropionate.","volume":"167","author":"Chapple","year":"1986","journal-title":"Planta"},{"key":"2021062510385148200_R8","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/BF01012085","article-title":"Chemical model for short-term induction in quaking aspen (Populus tremuloides) foliage against herbivores.","volume":"15","author":"Clausen","year":"1989","journal-title":"J Chem Ecol"},{"key":"2021062510385148200_R9","doi-asserted-by":"crossref","first-page":"124","DOI":"10.2307\/1940253","article-title":"Role of enemy-free space and plant quality in host-plant selection by willow beetles.","volume":"71","author":"Denno","year":"1990","journal-title":"Ecology"},{"key":"2021062510385148200_R10","volume-title":"Phenolglycoside einheimischer Salix-arten. 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