{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:46:20Z","timestamp":1791341180875,"version":"4.3.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cysteine (Cys) synthase [O-acetyl-l-Ser(thiol)-lyase, EC 4.2.99.8; CSase] is responsible for the final step in biosynthesis of Cys. Transgenic tobacco (Nicotiana tabacum; F1) plants with enhanced CSase activities in the cytosol and in the chloroplasts were generated by cross-fertilization of two transformants expressing cytosolic CSase or chloroplastic CSase. The F1transgenic plants were highly tolerant to toxic sulfur dioxide and sulfite. Upon fumigation with 0.1 \u03bcL L\u22121 sulfur dioxide, the Cys and glutathione contents in leaves of F1 plants were increased significantly, but not in leaves of non-transformed control plants. Furthermore, the leaves of F1 plants exhibited the increased resistance to paraquat, a herbicide generating active oxygen species.<\/jats:p>","DOI":"10.1104\/pp.126.3.973","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T04:59:39Z","timestamp":1027745979000},"page":"973-980","source":"Crossref","is-referenced-by-count":129,"title":["Cysteine Synthase Overexpression in Tobacco Confers Tolerance to Sulfur-Containing Environmental Pollutants"],"prefix":"10.1093","volume":"126","author":[{"given":"Masaaki","family":"Noji","sequence":"first","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, Department of Molecular Biology and Biotechnology, Chiba University, Yayoi-cho 1\u201333, Inage-ku, Chiba 263\u20138522, Japan (M.N., M.S., M.N., K.S.); and"},{"name":"Graduate School of Pharmaceutical Sciences, Department of Molecular Biology and Biotechnology, Chiba University, Yayoi-cho 1\u201333, Inage-ku, Chiba 263\u20138522, Japan (M.N., M.S., 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