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Colinearity was restricted to five genic and two intergenic regions representing &amp;lt;35% of the two sequences. In each interval separating the seven conserved regions, the number and type of repetitive elements were completely different between the two homologous sequences, and a single gene was absent in one cultivar. In both cultivars, the nonconserved regions consisted of \u223c53% repetitive sequences mainly represented by long-terminal repeat retrotransposons that have inserted &amp;lt;1 million years ago. PCR-based analysis of intergenic regions at the Rph7 locus and at three other independent loci in 41 H. vulgare lines indicated large haplotype variability in the cultivated barley gene pool. Together, our data indicate rapid and recent divergence at homologous loci in the genome of H. vulgare, possibly providing the molecular mechanism for the generation of high diversity in the barley gene pool. Finally, comparative analysis of the gene composition in barley, wheat (Triticum aestivum), rice (Oryza sativa), and sorghum (Sorghum bicolor) suggested massive gene movements at the Rph7 locus in the Triticeae lineage.<\/jats:p>","DOI":"10.1105\/tpc.104.028225","type":"journal-article","created":{"date-parts":[[2005,1,19]],"date-time":"2005-01-19T20:33:19Z","timestamp":1106166799000},"page":"361-374","source":"Crossref","is-referenced-by-count":67,"title":["Large Intraspecific Haplotype Variability at the\n                    <i>Rph7<\/i>\n                    Locus Results from Rapid and Recent Divergence in the Barley Genome"],"prefix":"10.1093","volume":"17","author":[{"given":"Beatrice","family":"Scherrer","sequence":"first","affiliation":[{"name":"Institute of Plant Biology, University of Zu\u0308rich, 8008 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwige","family":"Isidore","sequence":"additional","affiliation":[{"name":"Institute of Plant Biology, University of Zu\u0308rich, 8008 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Klein","sequence":"additional","affiliation":[{"name":"Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, Texas 77843-2123"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-soon","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, Texas 77843-2123"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bellec","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unite\u0301 de Ge\u0301nomique Ve\u0301ge\u0301tale, CP 5708, 91057 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boulos","family":"Chalhoub","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique, Unite\u0301 de Ge\u0301nomique Ve\u0301ge\u0301tale, CP 5708, 91057 Evry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Keller","sequence":"additional","affiliation":[{"name":"Institute of Plant Biology, University of Zu\u0308rich, 8008 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Feuillet","sequence":"additional","affiliation":[{"name":"Institute of Plant Biology, University of Zu\u0308rich, 8008 Zu\u0308rich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,2,1]]},"reference":[{"key":"2021040616145136400_b1","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"2021040616145136400_b2","first-page":"2025","volume":"149","year":"1998","journal-title":"Retrotransposon invasion into heterochromatin. 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