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We then investigated the change in the Arabidopsis secretome in response to salicylic acid and identified several proteins involved in pathogen response. One of these, a secreted lipase with a GDSL-like motif designated GDSL LIPASE1 (GLIP1), was further characterized for its function in disease resistance. glip1 plants were markedly more susceptible to infection by the necrotrophic fungus Alternaria brassicicola compared with the parental wild-type plants. The recombinant GLIP1 protein possessed lipase and antimicrobial activities that directly disrupt fungal spore integrity. Furthermore, GLIP1 appeared to trigger systemic resistance signaling in plants when challenged with A. brassicicola, because pretreatment of the glip1 mutant with recombinant GLIP1 protein inhibited A. brassicicola\u2013induced cell death in both peripheral and distal leaves. Moreover, glip1 showed altered expression of defense- and ethylene-related genes. GLIP1 transcription was increased by ethephon, the ethylene releaser, but not by salicylic acid or jasmonic acid. These results suggest that GLIP1, in association with ethylene signaling, may be a critical component in plant resistance to A. brassicicola.<\/jats:p>","DOI":"10.1105\/tpc.105.034819","type":"journal-article","created":{"date-parts":[[2005,8,27]],"date-time":"2005-08-27T00:33:44Z","timestamp":1125102824000},"page":"2832-2847","source":"Crossref","is-referenced-by-count":325,"title":["Secretome Analysis Reveals an<i>Arabidopsis<\/i>Lipase Involved in Defense against<i>Alternaria brassicicola<\/i>\u00a0"],"prefix":"10.1093","volume":"17","author":[{"given":"Il Seok","family":"Oh","sequence":"first","affiliation":[{"name":"\u00a0School of Life Sciences and Biotechnology \u00a0Korea University \u00a0Seoul 136-701 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ae Ran","family":"Park","sequence":"additional","affiliation":[{"name":"\u00a0Kumho Life and Environmental Science Laboratory \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Seok","family":"Bae","sequence":"additional","affiliation":[{"name":"\u00a0Kumho Life and Environmental Science Laboratory \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Jae","family":"Kwon","sequence":"additional","affiliation":[{"name":"\u00a0School of Life Sciences and Biotechnology \u00a0Korea University \u00a0Seoul 136-701 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Soon","family":"Kim","sequence":"additional","affiliation":[{"name":"\u00a0Kumho Life and Environmental Science Laboratory \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Lee","sequence":"additional","affiliation":[{"name":"\u00a0Kumho Life and Environmental Science Laboratory \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Young","family":"Kang","sequence":"additional","affiliation":[{"name":"\u00a0Kumho Life and Environmental Science Laboratory \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumin","family":"Lee","sequence":"additional","affiliation":[{"name":"\u00a0Kumho Life and Environmental Science Laboratory \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonsook","family":"Cheong","sequence":"additional","affiliation":[{"name":"\u00a0Department of Genetic Engineering \u00a0Chosun University \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ohkmae K.","family":"Park","sequence":"additional","affiliation":[{"name":"\u00a0School of Life Sciences and Biotechnology \u00a0Korea University \u00a0Seoul 136-701 \u00a0Korea"},{"name":"\u00a0Kumho Life and Environmental Science Laboratory \u00a0Gwangju 500-712 \u00a0Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,8,26]]},"reference":[{"key":"2021040616281588600_b1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0092-8674(00)81405-1","volume":"92","author":"Alvarez","year":"1998","journal-title":"Cell"},{"key":"2021040616281588600_b2","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1046\/j.1365-313X.2003.01907.x","volume":"36","author":"Bae","year":"2003","journal-title":"Plant J."},{"key":"2021040616281588600_b3","doi-asserted-by":"crossref","first-page":"20807","DOI":"10.1016\/S0021-9258(17)31891-4","volume":"269","author":"Barondes","year":"1994","journal-title":"J. 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