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We localized Chlamydomonas CRR1 to the nucleus in mustard (Sinapis alba) seedlings, a location consistent with its function as a transcription factor. The Zn binding SBP domain of CRR1 binds copper ions in vitro. Cu(I) can replace Zn(II), but the Cu(II) form is unstable. The DNA binding activity is inhibited in vitro by Cu(II) or Hg(II) ions, which also prevent activation of transcription in vivo, but not by Co(II) or Ni(II), which have no effect in vivo. Copper inhibition of DNA binding is reduced by mutation of a conserved His residue. These results implicate the SBP domain in copper sensing. Deletion of a C-terminal metallothionein-like Cys-rich domain impacted neither nutritional copper signaling nor the effect of mercuric supplementation, but rendered CRR1 insensitive to hypoxia and to nickel supplementation, which normally activate the copper deficiency regulon in wild-type cells. Strains carrying the crr1-\u0394Cys allele upregulate ZRT genes and hyperaccumulate Zn(II), suggesting that the effect of nickel ions may be revealing a role for the C-terminal domain of CRR1 in zinc homeostasis in Chlamydomonas.<\/jats:p>","DOI":"10.1105\/tpc.110.080069","type":"journal-article","created":{"date-parts":[[2010,12,4]],"date-time":"2010-12-04T05:58:47Z","timestamp":1291442327000},"page":"4098-4113","source":"Crossref","is-referenced-by-count":100,"title":["The CRR1 Nutritional Copper Sensor in <i>Chlamydomonas<\/i> Contains Two Distinct Metal-Responsive Domains\n\u00a0\n\u00a0"],"prefix":"10.1093","volume":"22","author":[{"given":"Frederik","family":"Sommer","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569"},{"name":"Max Planck Institute of Molecular Plant Physiology-Golm, 14476 Potsdam, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janette","family":"Kropat","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davin","family":"Malasarn","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Grossoehme","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas 77843-2128"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"Giedroc","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabeeha S.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569"},{"name":"Institute for Genomics and Proteomics, University of California, Los Angeles, California 90095-1569"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,12,3]]},"reference":[{"key":"2021040622045301800_b1","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1128\/EC.00205-07","article-title":"FEA1, FEA2, and FRE1, encoding two homologous secreted proteins and a candidate ferrireductase, are expressed coordinately with FOX1 and FTR1 in iron-deficient Chlamydomonas reinhardtii","volume":"6","author":"Allen","year":"2007","journal-title":"Eukaryot. 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