{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:32:11Z","timestamp":1790775131980,"version":"4.1.0"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Riboswitches are natural RNA elements that posttranscriptionally regulate gene expression by binding small molecules and thereby autonomously control intracellular levels of these metabolites. Although riboswitch-based mechanisms have been examined extensively, the integration of their activity with global physiology and metabolism has been largely overlooked. Here, we explored the regulation of thiamin biosynthesis and the consequences of thiamin pyrophosphate riboswitch deficiency on metabolism in Arabidopsis thaliana. Our results show that thiamin biosynthesis is largely regulated by the circadian clock via the activity of the THIAMIN C SYNTHASE (THIC \u00a0) promoter, while the riboswitch located at the 3\u2032 untranslated region of this gene controls overall thiamin biosynthesis. Surprisingly, the results also indicate that the rate of thiamin biosynthesis directs the activity of thiamin-requiring enzymes and consecutively determines the rate of carbohydrate oxidation via the tricarboxylic acid cycle and pentose-phosphate pathway. Our model suggests that in Arabidopsis, the THIC promoter and the thiamin-pyrophosphate riboswitch act simultaneously to tightly regulate thiamin biosynthesis in a circadian manner and consequently sense and control vital points of core cellular metabolism.<\/jats:p>","DOI":"10.1105\/tpc.112.106385","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T08:12:36Z","timestamp":1358928756000},"page":"288-307","source":"Crossref","is-referenced-by-count":111,"title":["Orchestration of Thiamin Biosynthesis and Central Metabolism by Combined Action of the Thiamin Pyrophosphate Riboswitch and the Circadian Clock in <i>Arabidopsis<\/i>\n\u00a0\n\u00a0"],"prefix":"10.1093","volume":"25","author":[{"given":"Samuel E.","family":"Bocobza","sequence":"first","affiliation":[{"name":"Department of Plant Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Malitsky","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner L.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam-Golm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriano","family":"Nunes-Nesi","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam-Golm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagit","family":"Meir","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Ben Gurion University at the Negev, 84105 Beer Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisdair R.","family":"Fernie","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fur Molekulare Pflanzenphysiologie, 14476 Potsdam-Golm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asaph","family":"Aharoni","sequence":"additional","affiliation":[{"name":"Department of Plant Sciences, Weizmann Institute of Science, 76100 Rehovot, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,1,22]]},"reference":[{"key":"2021040706492164200_b1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s11103-007-9205-4","article-title":"Thiamin pyrophosphokinase is required for thiamin cofactor activation in Arabidopsis","volume":"65","author":"Ajjawi","year":"2007","journal-title":"Plant Mol. 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