{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:35:39Z","timestamp":1792096539331,"version":"4.4.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although magnesium (Mg2+) is the most abundant divalent cation in plant cells, little is known about the mechanism of Mg2+ uptake by plant roots. Here, we report a key function of Magnesium Transport6 (MGT6)\/Mitochondrial RNA Splicing2-4 in Mg2+ uptake and low-Mg2+ tolerance in Arabidopsis thaliana. MGT6 is expressed mainly in plant aerial tissues when Mg2+ levels are high in the soil or growth medium. Its expression is highly induced in the roots during Mg2+ deficiency, suggesting a role for MGT6 in response to the low-Mg2+ status in roots. Silencing of MGT6 in transgenic plants by RNA interference (RNAi) resulted in growth retardation under the low-Mg2+ condition, and the phenotype was restored to normal growth after RNAi plants were transferred to Mg2+-sufficient medium. RNAi plants contained lower levels of Mg2+ compared with wild-type plants under low Mg2+ but not under Mg2+-sufficient conditions. Further analysis indicated that MGT6 was localized in the plasma membrane and played a key role in Mg2+ uptake by roots under Mg2+ limitation. We conclude that MGT6 mediates Mg2+ uptake in roots and is required for plant adaptation to a low-Mg2+ environment.<\/jats:p>","DOI":"10.1105\/tpc.114.124628","type":"journal-article","created":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T02:21:39Z","timestamp":1399083699000},"page":"2234-2248","source":"Crossref","is-referenced-by-count":122,"title":["<i>Arabidopsis<\/i>\n                    Transporter MGT6 Mediates Magnesium Uptake and Is Required for Growth under Magnesium Limitation"],"prefix":"10.1093","volume":"26","author":[{"given":"Dandan","family":"Mao","sequence":"first","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"},{"name":"Nanjing University\u2013Nanjing Forestry University Joint Institute for Plant Molecular Biology, State Key Laboratory for Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfu","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanjing University\u2013Nanjing Forestry University Joint Institute for Plant Molecular Biology, State Key Laboratory for Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renjie","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghua","family":"Yang","sequence":"additional","affiliation":[{"name":"Nanjing University\u2013Nanjing Forestry University Joint Institute for Plant Molecular Biology, State Key Laboratory for Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisen","family":"Shi","sequence":"additional","affiliation":[{"name":"Nanjing University\u2013Nanjing Forestry University Joint Institute for Plant Molecular Biology, MOF Key Laboratory of Forest Genetics and Biotechnology, Nanjing Forestry University, Nanjing 210037, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbi","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongping","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Hunan Normal University, Changsha 410081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Luan","sequence":"additional","affiliation":[{"name":"Nanjing University\u2013Nanjing Forestry University Joint Institute for Plant Molecular Biology, State Key Laboratory for Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China"},{"name":"Department of Plant and Microbial Biology, University of California, Berkeley, California 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,2]]},"reference":[{"key":"2021040716210218100_b1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1046\/j.1365-313X.1997.11030605.x","article-title":"A glucocorticoid-mediated transcriptional induction system in transgenic plants","volume":"11","author":"Aoyama","year":"1997","journal-title":"Plant J."},{"key":"2021040716210218100_b2","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/j.1460-2075.1990.tb08249.x","article-title":"Expression of potyviral polyproteins in transgenic plants reveals three proteolytic activities required for complete 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Plant."},{"key":"2021040716210218100_b11","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1002\/j.1460-2075.1987.tb02730.x","article-title":"GUS fusions: \u03b2-Glucuronidase as a sensitive and versatile gene fusion marker in higher plants","volume":"6","author":"Jefferson","year":"1987","journal-title":"EMBO J."},{"key":"2021040716210218100_b12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00438-005-0011-x","article-title":"Transport of magnesium and other divalent cations: Evolution of the 2-TM-GxN proteins in the MIT superfamily","volume":"274","author":"Knoop","year":"2005","journal-title":"Mol. Genet. 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