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The interface between the plant host and the biotrophic pathogen thus represents a major battleground for plant-pathogen interactions. Increasing evidence shows that cellular trafficking plays an important role in plant immunity. Here, we report that Arabidopsis thaliana ENHANCED DISEASE RESISTANCE4 (EDR4) plays a negative role in resistance to powdery mildew and that the enhanced disease resistance in edr4 mutants requires salicylic acid signaling. EDR4 mainly localizes to the plasma membrane and endosomal compartments. Genetic analyses show that EDR4 and EDR1 function in the same genetic pathway. EDR1 and EDR4 accumulate at the penetration site of powdery mildew infection, and EDR4 physically interacts with EDR1, recruiting EDR1 to the fungal penetration site. In addition, EDR4 interacts with CLATHRIN HEAVY CHAIN2 (CHC2), and edr4 mutants show reduced endocytosis rates. Taken together, our data indicate that EDR4 associates with CHC2 and modulates plant immunity by regulating the relocation of EDR1 in Arabidopsis.<\/jats:p>","DOI":"10.1105\/tpc.114.134668","type":"journal-article","created":{"date-parts":[[2015,3,7]],"date-time":"2015-03-07T03:03:13Z","timestamp":1425697393000},"page":"857-873","source":"Crossref","is-referenced-by-count":78,"title":["ENHANCED DISEASE RESISTANCE4 Associates with CLATHRIN HEAVY CHAIN2 and Modulates Plant Immunity by Regulating Relocation of EDR1 in Arabidopsis"],"prefix":"10.1093","volume":"27","author":[{"given":"Guangheng","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofei","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaosheng","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Genomics, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingzhong","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"2021040908344869000_b1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1126\/science.1086391","article-title":"Genome-wide insertional mutagenesis of Arabidopsis thaliana","volume":"301","author":"Alonso","year":"2003","journal-title":"Science"},{"key":"2021040908344869000_b2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1126\/science.1203877","article-title":"Evidence for network evolution in an Arabidopsis interactome map","volume":"333","author":"Arabidopsis Interactome Mapping Consortium","year":"2011","journal-title":"Science"},{"key":"2021040908344869000_b3","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.1105\/tpc.109.067678","article-title":"MAP kinase phosphatase1 and protein tyrosine phosphatase1 are repressors of salicylic acid synthesis and SNC1-mediated responses in Arabidopsis","volume":"21","author":"Bartels","year":"2009","journal-title":"Plant Cell"},{"key":"2021040908344869000_b4","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1105\/tpc.105.039982","article-title":"Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the Nudix hydrolase NUDT7","volume":"18","author":"Bartsch","year":"2006","journal-title":"Plant Cell"},{"key":"2021040908344869000_b5","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1073\/pnas.0500012102","article-title":"Recruitment and interaction dynamics of plant penetration resistance components in a plasma membrane microdomain","volume":"102","author":"Bhat","year":"2005","journal-title":"Proc. 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