{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:13:09Z","timestamp":1769242389068,"version":"3.49.0"},"reference-count":38,"publisher":"International Union of Crystallography (IUCr)","issue":"7","license":[{"start":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T00:00:00Z","timestamp":1370649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2013,6,8]],"date-time":"2013-06-08T00:00:00Z","timestamp":1370649600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst Sect C","Acta Crystallogr C","Acta Crystallogr Sect C","Acta Crystallogr Sect C Cryst Struct Commun"],"published-print":{"date-parts":[[2013,7,15]]},"abstract":"<jats:p>The crystal structures of three new solvates of olanzapine [systematic name: 2-methyl-4-(4-methylpiperazin-1-yl)-10<jats:italic>H<\/jats:italic>-thieno[2,3-<jats:italic>b<\/jats:italic>][1,5]benzodiazepine], namely olanzapine acetic acid monosolvate, C<jats:sub>17<\/jats:sub>H<jats:sub>20<\/jats:sub>N<jats:sub>4<\/jats:sub>S\u00b7C<jats:sub>2<\/jats:sub>H<jats:sub>4<\/jats:sub>O<jats:sub>2<\/jats:sub>, (I), olanzapine propan-2-ol hemisolvate monohydrate, C<jats:sub>17<\/jats:sub>H<jats:sub>20<\/jats:sub>N<jats:sub>4<\/jats:sub>S\u00b70.5C<jats:sub>3<\/jats:sub>H<jats:sub>8<\/jats:sub>O\u00b7H<jats:sub>2<\/jats:sub>O, (II), and olanzapine propan-2-one hemisolvate monohydrate, C<jats:sub>17<\/jats:sub>H<jats:sub>20<\/jats:sub>N<jats:sub>4<\/jats:sub>S\u00b70.5C<jats:sub>3<\/jats:sub>H<jats:sub>6<\/jats:sub>O\u00b7H<jats:sub>2<\/jats:sub>O, (III), are presented and compared with other known olanzapine forms. There is a fairly close resemblance of the molecular conformation for all studied analogues. The crystal structures are built up through olanzapine dimers, which are characterized<jats:italic>via<\/jats:italic>C\u2014H...\u03c0 interactions between the aliphatic fragment (1-methylpiperazin-4-yl) and the aromatic fragment (benzene system). All solvent (guest) molecules participate in hydrogen-bonding networks. The crystal packing is sustained<jats:italic>via<\/jats:italic>intermolecular N<jats:sub>host<\/jats:sub>\u2014H...O<jats:sub>guest<\/jats:sub>, O<jats:sub>guest<\/jats:sub>\u2014H...N<jats:sub>host<\/jats:sub>, O<jats:sub>guest<\/jats:sub>\u2014H...O<jats:sub>guest<\/jats:sub>and C<jats:sub>host<\/jats:sub>\u2014H...O<jats:sub>guest<\/jats:sub>hydrogen bonds. It should be noted that the solvent propan-2-ol in (II) and propan-2-one in (III) show orientational disorder. The propan-2-ol molecule lies close to a twofold axis, while the propan-2-one molecule resides strictly on a twofold axis through the carbonyl C atom. In both cases, the water molecules present positional disorder of the H atoms.<\/jats:p>","DOI":"10.1107\/s010827011301411x","type":"journal-article","created":{"date-parts":[[2013,6,7]],"date-time":"2013-06-07T15:35:58Z","timestamp":1370619358000},"page":"781-786","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":14,"title":["Three new olanzapine structures: the acetic acid monosolvate, and the propan-2-ol and propan-2-one hemisolvate monohydrates"],"prefix":"10.1107","volume":"69","author":[{"given":"Joanna","family":"Bojarska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waldemar","family":"Maniukiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Les\u0142aw","family":"Siero\u0144","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2013,6,8]]},"reference":[{"key":"ov3029_bb1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1107\/S0108768102003890","volume":"58","author":"Allen","year":"2002","journal-title":"Acta Cryst. 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