{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T13:56:14Z","timestamp":1736603774648,"version":"3.32.0"},"reference-count":0,"publisher":"International Union of Crystallography (IUCr)","issue":"1","license":[{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[1999,2,1]],"date-time":"1999-02-01T00:00:00Z","timestamp":917827200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr B Struct Sci","Acta Cryst B","Acta Cryst Sect B","Acta Crystallogr B","Acta Crystallogr Sect B","Acta Crystallogr Sect B Struct Sci"],"accepted":{"date-parts":[[1998,7,27]]},"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:p>The dipeptide L-Leu-L-Val can crystallize as a hydrate in the hexagonal space group <jats:italic>P<\/jats:italic>6<jats:sub>5<\/jats:sub> [G\u00f6rbitz &amp; Gundersen (1996). <jats:italic>Acta Chem. Scand.<\/jats:italic> \n                  <jats:bold>50<\/jats:bold>, 537\u2013543], but forms 1:1 solvates when methanol, ethanol and 2-propanol are used as precipitating agents. The structures of these complexes can be divided into hydrophobic and hydrophilic layers. The alcohol molecules are embedded in the hydrophobic layers, but with the hydroxyl groups as crucial parts of the hydrogen-bonding network. L-Leucyl-L-valine\u2013methanol (1\/1) crystallizes in the space group <jats:italic>P<\/jats:italic>2<jats:sub>1<\/jats:sub> with <jats:italic>Z<\/jats:italic> = 2. L-Leucyl-L-valine\u2013ethanol (1\/1) has very special systematic absences, and the structure could not be solved with direct methods. Unraveling the actual build-up of the crystal was an unusual process involving modeling with molecular graphics programs. The solution shows a structure which formally belongs to the space group <jats:italic>P<\/jats:italic>2<jats:sub>1<\/jats:sub>, with four dipeptide molecules and four solvent molecules in the asymmetric unit (<jats:italic>Z<\/jats:italic> = 8). Additional non-crystallographic symmetry in three dimensions fixes all cell angles, including \u03b2, to 90\u00b0. L-Leucyl-L-valine\u20132-propanol (1\/1) is structurally closely related to the ethanol solvate, but owing to a rare type of packing disorder the length of the <jats:italic>a<\/jats:italic> axis is halved (<jats:italic>Z<\/jats:italic> = 4, <jats:italic>P<\/jats:italic>2<jats:sub>1<\/jats:sub>2<jats:sub>1<\/jats:sub>2<jats:sub>1<\/jats:sub>). The hydrogen-bonding pattern is still the same as in the ethanol solvate, which means that the hydrogen-bond periodicity along the <jats:italic>a<\/jats:italic> axis in the 2-propanol solvate is two unit-cell lengths.<\/jats:p>","DOI":"10.1107\/s0108768198010192","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T05:09:34Z","timestamp":1027746574000},"page":"104-113","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":12,"title":["Symmetry, pseudosymmetry and packing disorder in the alcohol solvates of <scp>L<\/scp>-leucyl-<scp>L<\/scp>-valine"],"prefix":"10.1107","volume":"55","author":[{"given":"Carl Henrik","family":"G\u00f6rbitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirin","family":"Torgersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[1999,2,1]]},"container-title":["Acta Crystallographica Section B Structural Science"],"original-title":[],"link":[{"URL":"http:\/\/journals.iucr.org\/b\/issues\/1999\/01\/00\/ha0173\/ha0173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.iucr.org\/b\/issues\/1999\/01\/00\/ha0173\/ha0173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T12:59:13Z","timestamp":1736600353000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.iucr.org\/paper?S0108768198010192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["S0108768198010192"],"URL":"https:\/\/doi.org\/10.1107\/s0108768198010192","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.1107\/S0108768198010192\/ha0173sup1.cif","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S0108768198010192\/ha0173lvesup2.hkl","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S0108768198010192\/ha0173lvmsup3.hkl","asserted-by":"subject"},{"id-type":"doi","id":"10.1107\/S0108768198010192\/ha0173lv2psup4.hkl","asserted-by":"subject"}]},"ISSN":["0108-7681"],"issn-type":[{"type":"print","value":"0108-7681"}],"subject":[],"published":{"date-parts":[[1999,2,1]]},"assertion":[{"value":"Acta Crystallographica Section B: Structural Science","order":0,"name":"journal","label":"Publication","explanation":{"URL":"http:\/\/journals.iucr.org\/b"},"group":{"name":"general","label":"General"}},{"value":"research papers","order":1,"name":"content_type","label":"Content type","explanation":{"URL":"https:\/\/journals.iucr.org\/b\/services\/notesforauthors.html"},"group":{"name":"general","label":"General"}},{"value":"Available","URL":"http:\/\/scripts.iucr.org\/cgi-bin\/citedin?ha0173","order":2,"name":"article_metrics","label":"Article metrics","group":{"name":"general","label":"General"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"23 April 1998","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication history"}},{"value":"27 July 1998","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication history"}},{"value":"1 February 1999","order":2,"name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication history"}},{"value":"This article has supporting information","name":"supplementary_materials","label":"Supplementary materials","explanation":{"URL":"http:\/\/scripts.iucr.org\/cgi-bin\/sendsup?ha0173"}},{"value":"\u00a9 1999 International Union of Crystallography","order":0,"name":"copyright","label":"Copyright","explanation":{"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},"group":{"name":"copyright_and_licensing","label":"Copyright and licencing"}}]}}