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Vaccine candidates have been identified, including<jats:italic>Schistosoma mansoni<\/jats:italic>venom allergen-like proteins (SmVALs) from the SCP\/TAPS (sperm-coating protein\/Tpx\/antigen 5\/pathogenesis related-1\/Sc7) superfamily. The first SmVAL structure, SmVAL4, was refined to a resolution limit of 2.16\u2005\u00c5. SmVAL4 has a unique structure that could not be predicted from homologous structures, with longer loops and an unusual C-terminal extension. SmVAL4 has the characteristic \u03b1\/\u03b2-sandwich and central SCP\/TAPS cavity. Furthermore, SmVAL4 has only one of the signature CAP cavity tetrad amino-acid residues and is missing the histidines that coordinate divalent cations such as Zn<jats:sup>2+<\/jats:sup>in other SCP\/TAPS proteins. SmVAL4 has a cavity between \u03b1-helices 1 and 4 that was observed to bind lipids in tablysin-15, suggesting the ability to bind lipids. Subsequently, SmVAL4 was shown to bind cholesterol<jats:italic>in vitro<\/jats:italic>. 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