{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:32:13Z","timestamp":1791725533709,"version":"4.3.4"},"reference-count":83,"publisher":"International Union of Crystallography (IUCr)","issue":"4","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM123159"],"award-info":[{"award-number":["GM123159"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016436","name":"Nebraska Tobacco Settlement Biomedical Research Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100016436","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["J Synchrotron Rad","J Synchrotron Radiat"],"accepted":{"date-parts":[[2019,4,25]]},"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:p>Cysteine is a rare but functionally important amino acid that is often subject to covalent modification. Cysteine oxidation plays an important role in many human disease processes, and basal levels of cysteine oxidation are required for proper cellular function. Because reactive cysteine residues are typically ionized to the thiolate anion (Cys-S<jats:sup>\u2212<\/jats:sup>), their formation of a covalent bond alters the electrostatic and steric environment of the active site. X-ray-induced photo-oxidation to sulfenic acids (Cys-SOH) can recapitulate some aspects of the changes that occur under physiological conditions. Here we propose how site-specific cysteine photo-oxidation can be used to interrogate ensuing changes in protein structure and dynamics at atomic resolution. Although this powerful approach can connect cysteine covalent modification to global protein conformational changes and function, careful biochemical validation must accompany all such studies to exclude misleading artifacts. New types of X-ray crystallography experiments and powerful computational methods are creating new opportunities to connect conformational dynamics to catalysis for the large class of systems that use covalently modified cysteine residues for catalysis or regulation.<\/jats:p>","DOI":"10.1107\/s160057751900568x","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T14:56:04Z","timestamp":1560437764000},"page":"958-966","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":25,"title":["Shining light on cysteine modification: connecting protein conformational dynamics to catalysis and regulation"],"prefix":"10.1107","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-841X","authenticated-orcid":true,"given":"Henry","family":"van den Bedem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2019,6,13]]},"reference":[{"key":"gm5060_bb1","doi-asserted-by":"crossref","first-page":"18748","DOI":"10.1073\/pnas.0709379104","volume":"104","author":"Aleyasin","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"gm5060_bb2","doi-asserted-by":"crossref","first-page":"e1000349","DOI":"10.1371\/journal.pbio.1000349","volume":"8","author":"Aron","year":"2010","journal-title":"PLoS Biol."},{"key":"gm5060_bb3","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1021\/acs.jcim.8b00454","volume":"58","author":"Awoonor-Williams","year":"2018","journal-title":"J. Chem. Inf. Model."},{"key":"gm5060_bb4","unstructured":"Backus, K. M. (2019). Activity-Based Protein Profiling, edited by B. F. Cravatt, K.-L. Hsu & E. Weerapana, pp. 375-417. Cham: Springer International Publishing."},{"key":"gm5060_bb5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00775-017-1509-5","volume":"23","author":"Barbieri","year":"2018","journal-title":"J. Biol. Inorg. Chem."},{"key":"gm5060_bb6","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.drudis.2015.05.005","volume":"20","author":"Bauer","year":"2015","journal-title":"Drug Discov. Today"},{"key":"gm5060_bb7","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nmeth.2592","volume":"10","author":"Bedem","year":"2013","journal-title":"Nat. Methods"},{"key":"gm5060_bb8","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1107\/S0907444909030613","volume":"65","author":"Bedem","year":"2009","journal-title":"Acta Cryst. D"},{"key":"gm5060_bb9","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nmeth.3324","volume":"12","author":"Bedem","year":"2015","journal-title":"Nat. Methods"},{"key":"gm5060_bb10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"gm5060_bb11","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1074\/jbc.M806599200","volume":"284","author":"Blackinton","year":"2009","journal-title":"J. Biol. Chem."},{"key":"gm5060_bb12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1742-4658.2012.08655.x","volume":"280","author":"B\u00f6hmer","year":"2013","journal-title":"FEBS J."},{"key":"gm5060_bb13","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"gm5060_bb14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.freeradbiomed.2017.01.018","volume":"104","author":"Bonilha","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"gm5060_bb15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jmps.2015.06.006","volume":"83","author":"Budday","year":"2015","journal-title":"J. Mech. Phys. Solids"},{"key":"gm5060_bb16","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1021\/acs.jcim.8b00267","volume":"58","author":"Budday","year":"2018","journal-title":"J. Chem. Inf. Model."},{"key":"gm5060_bb17","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1107\/S1600576718005241","volume":"51","author":"Bury","year":"2018","journal-title":"J. Appl. Cryst."},{"key":"gm5060_bb18","doi-asserted-by":"crossref","first-page":"9103","DOI":"10.1073\/pnas.0402959101","volume":"101","author":"Canet-Avil\u00e9s","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"gm5060_bb19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bcp.2014.11.012","volume":"93","author":"Cao","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"gm5060_bb20","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1089\/ars.2013.5446","volume":"21","author":"Cao","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"gm5060_bb21","doi-asserted-by":"crossref","first-page":"10665","DOI":"10.1021\/acs.jmedchem.8b01308","volume":"61","author":"Casimiro-Garcia","year":"2018","journal-title":"J. Med. Chem."},{"key":"gm5060_bb22","doi-asserted-by":"crossref","first-page":"11742","DOI":"10.1073\/pnas.0804828105","volume":"105","author":"Colletier","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"gm5060_bb23","doi-asserted-by":"crossref","unstructured":"DasGupta, M., Budday, D., Madzelan, P., Seravalli, J., Hayes, B., Sierra, R. G., Alonso-Mori, R., Brewster, A. S., Sauter, N. K., Applegate, G. A., Tiwari, V., Berkowitz, D. B., Thompson, M. C., Fraser, J. S., Wall, M. E., van den Bedem, H. & Wilson, M. A. (2019). bioRxiv 524751; doi: 10.1101\/524751.","DOI":"10.1101\/524751"},{"key":"gm5060_bb24","doi-asserted-by":"crossref","first-page":"e1004051","DOI":"10.1371\/journal.pcbi.1004051","volume":"11","author":"Defelipe","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"gm5060_bb25","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1021\/acschembio.8b00633","volume":"13","author":"Drechsel","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"gm5060_bb26","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1146\/annurev-biophys-042910-155245","volume":"41","author":"Dror","year":"2012","journal-title":"Annu. Rev. Biophys."},{"key":"gm5060_bb27","doi-asserted-by":"crossref","first-page":"16247","DOI":"10.1073\/pnas.1111325108","volume":"108","author":"Fraser","year":"2011","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"gm5060_bb28","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1021\/bi401700f","volume":"53","author":"Garc\u00eda-Santamarina","year":"2014","journal-title":"Biochemistry"},{"key":"gm5060_bb29","unstructured":"Garman, E. F. & Weik, M. (2017). Protein Crystallography: Methods and Protocols, edited by A. Wlodawer, Z. Dauter & M. Jaskolski, pp. 467-489. New York: Springer."},{"key":"gm5060_bb30","doi-asserted-by":"crossref","unstructured":"Gehringer, M. & Laufer, S. A. (2019). J. Med. Chem. doi:10.1021\/acs.jmedchem.8b01153.","DOI":"10.1021\/acs.jmedchem.8b01153"},{"key":"gm5060_bb31","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1107\/S090904951203943X","volume":"19","author":"George","year":"2012","journal-title":"J. Synchrotron Rad."},{"key":"gm5060_bb32","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/nature09536","volume":"468","author":"Guzman","year":"2010","journal-title":"Nature"},{"key":"gm5060_bb33","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature20571","volume":"540","author":"Hekstra","year":"2016","journal-title":"Nature"},{"key":"gm5060_bb34","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nature06410","volume":"450","author":"Henzler-Wildman","year":"2007","journal-title":"Nature"},{"key":"gm5060_bb35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/pro.2713","volume":"25","author":"Janowski","year":"2016","journal-title":"Protein Sci."},{"key":"gm5060_bb36","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1093\/hmg\/dds325","volume":"21","author":"Joselin","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"gm5060_bb37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nrc2980","volume":"11","author":"Julien","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"gm5060_bb38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1107\/S2059798318017941","volume":"75","author":"Keedy","year":"2019","journal-title":"Acta Cryst. D"},{"key":"gm5060_bb39","doi-asserted-by":"crossref","first-page":"e1004507","DOI":"10.1371\/journal.pcbi.1004507","volume":"11","author":"Keedy","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"gm5060_bb40","doi-asserted-by":"crossref","first-page":"e07574","DOI":"10.7554\/eLife.07574","volume":"4","author":"Keedy","year":"2015","journal-title":"eLife"},{"key":"gm5060_bb41","doi-asserted-by":"crossref","first-page":"eaag2355","DOI":"10.1126\/science.aag2355","volume":"355","author":"Kim","year":"2017","journal-title":"Science"},{"key":"gm5060_bb42","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1126\/science.1251652","volume":"343","author":"K\u00fchlbrandt","year":"2014","journal-title":"Science"},{"key":"gm5060_bb43","doi-asserted-by":"crossref","first-page":"044003","DOI":"10.1063\/1.4972069","volume":"4","author":"Kupitz","year":"2017","journal-title":"Struct. Dyn."},{"key":"gm5060_bb44","doi-asserted-by":"crossref","first-page":"29651","DOI":"10.1074\/jbc.M110.147934","volume":"285","author":"Lakshminarasimhan","year":"2010","journal-title":"J. Biol. Chem."},{"key":"gm5060_bb45","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1093\/hmg\/dds155","volume":"21","author":"Lee","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"gm5060_bb46","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/prot.20660","volume":"61","author":"Li","year":"2005","journal-title":"Proteins"},{"key":"gm5060_bb47","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.chembiol.2012.12.006","volume":"20","author":"Liu","year":"2013","journal-title":"Chem. Biol."},{"key":"gm5060_bb48","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1021\/bi963094r","volume":"36","author":"Lohse","year":"1997","journal-title":"Biochemistry"},{"key":"gm5060_bb49","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1021\/ac990500e","volume":"71","author":"Maleknia","year":"1999","journal-title":"Anal. Chem."},{"key":"gm5060_bb50","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.redox.2014.02.006","volume":"2","author":"Marinho","year":"2014","journal-title":"Redox Biol."},{"key":"gm5060_bb51","doi-asserted-by":"crossref","first-page":"10288","DOI":"10.1021\/acs.jpcb.6b08109","volume":"120","author":"Mazmanian","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"gm5060_bb52","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nature01681","volume":"423","author":"Montfort","year":"2003","journal-title":"Nature"},{"key":"gm5060_bb53","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1471-4159.2011.07175.x","volume":"117","author":"Mullett","year":"2011","journal-title":"J. Neurochem."},{"key":"gm5060_bb54","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1021\/acs.jpclett.5b00491","volume":"6","author":"Mundlapati","year":"2015","journal-title":"J. Phys. Chem. Lett."},{"key":"gm5060_bb55","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.1997.6132","volume":"231","author":"Nagakubo","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"gm5060_bb56","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/nature12796","volume":"503","author":"Ostrem","year":"2013","journal-title":"Nature"},{"key":"gm5060_bb57","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1107\/S0907444912012553","volume":"68","author":"Owen","year":"2012","journal-title":"Acta Cryst. D"},{"key":"gm5060_bb58","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nchembio.1720","volume":"11","author":"Peralta","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"gm5060_bb59","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cbpa.2008.07.028","volume":"12","author":"Reddie","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"gm5060_bb60","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1074\/jbc.M114.597815","volume":"290","author":"Richarme","year":"2015","journal-title":"J. Biol. Chem."},{"key":"gm5060_bb61","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1089\/ars.2012.4521","volume":"18","author":"Roos","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"gm5060_bb62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1107\/S1600577516017343","volume":"24","author":"Russi","year":"2017","journal-title":"J. Synchrotron Rad."},{"key":"gm5060_bb63","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/NEN.0000000000000087","volume":"73","author":"Saito","year":"2014","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"gm5060_bb64","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nature01680","volume":"423","author":"Salmeen","year":"2003","journal-title":"Nature"},{"key":"gm5060_bb65","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1021\/ar00022a001","volume":"25","author":"Scheuer","year":"1992","journal-title":"Acc. Chem. Res."},{"key":"gm5060_bb66","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1126\/science.287.5458.1615","volume":"287","author":"Schlichting","year":"2000","journal-title":"Science"},{"key":"gm5060_bb67","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1021\/acschembio.8b00701","volume":"13","author":"Tashiro","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"gm5060_bb68","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1021\/bi500294h","volume":"53","author":"Tashiro","year":"2014","journal-title":"Biochemistry"},{"key":"gm5060_bb69","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1126\/science.1259357","volume":"346","author":"Tenboer","year":"2014","journal-title":"Science"},{"key":"gm5060_bb70","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.chembiol.2016.05.017","volume":"23","author":"Truong","year":"2016","journal-title":"Cell. Chem. Biol."},{"key":"gm5060_bb71","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cbpa.2015.11.004","volume":"30","author":"Visscher","year":"2016","journal-title":"Curr. Opin. Chem. Biol."},{"key":"gm5060_bb72","doi-asserted-by":"crossref","first-page":"17887","DOI":"10.1073\/pnas.1416744111","volume":"111","author":"Wall","year":"2014","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"gm5060_bb73","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/pro.2934","volume":"25","author":"Wang","year":"2016","journal-title":"Protein Sci."},{"key":"gm5060_bb74","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1021\/jo00422a034","volume":"42","author":"Whitesides","year":"1977","journal-title":"J. Org. Chem."},{"key":"gm5060_bb75","doi-asserted-by":"crossref","first-page":"9256","DOI":"10.1073\/pnas.1133288100","volume":"100","author":"Wilson","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"gm5060_bb76","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nchembio.85","volume":"4","author":"Winterbourn","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"gm5060_bb77","doi-asserted-by":"crossref","first-page":"7430","DOI":"10.1021\/bi800282d","volume":"47","author":"Witt","year":"2008","journal-title":"Biochemistry"},{"key":"gm5060_bb78","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1021\/ac0484629","volume":"77","author":"Xu","year":"2005","journal-title":"Anal. Chem."},{"key":"gm5060_bb79","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/jnc.14297","volume":"145","author":"Xu","year":"2018","journal-title":"J. Neurochem."},{"key":"gm5060_bb80","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tibs.2010.03.004","volume":"35","author":"Yip","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"gm5060_bb82","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1089\/ars.2017.7013","volume":"30","author":"Young","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"gm5060_bb83","doi-asserted-by":"crossref","first-page":"20551","DOI":"10.1073\/pnas.1315879110","volume":"110","author":"Zeldin","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"gm5060_bb84","doi-asserted-by":"crossref","first-page":"11183","DOI":"10.1021\/acs.jmedchem.8b01292","volume":"61","author":"Zundert","year":"2018","journal-title":"J. Med. Chem."}],"container-title":["Journal of Synchrotron Radiation"],"original-title":[],"link":[{"URL":"https:\/\/journals.iucr.org\/s\/issues\/2019\/04\/00\/gm5060\/gm5060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.iucr.org\/s\/issues\/2019\/04\/00\/gm5060\/gm5060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:03:07Z","timestamp":1736766187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.iucr.org\/paper?S160057751900568X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,13]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S160057751900568X"],"URL":"https:\/\/doi.org\/10.1107\/s160057751900568x","relation":{},"ISSN":["1600-5775"],"issn-type":[{"value":"1600-5775","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6,13]]},"assertion":[{"value":"Journal of Synchrotron Radiation","order":0,"name":"journal","label":"Publication","explanation":{"URL":"https:\/\/journals.iucr.org\/s"},"group":{"name":"general","label":"General"}},{"value":"research papers","order":1,"name":"content_type","label":"Content type","explanation":{"URL":"https:\/\/journals.iucr.org\/s\/services\/notesforauthors.html"},"group":{"name":"general","label":"General"}},{"value":"Available","URL":"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?gm5060","order":2,"name":"article_metrics","label":"Article metrics","group":{"name":"general","label":"General"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"28 February 2019","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication history"}},{"value":"25 April 2019","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication history"}},{"value":"13 June 2019","order":2,"name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication history"}},{"value":"\u00a9 2019 International Union of Crystallography","order":0,"name":"copyright","label":"Copyright","explanation":{"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},"group":{"name":"copyright_and_licensing","label":"Copyright and licencing"}}]}}