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A four sensor-field cloverleaf design is optimized for the investigation of planar samples and operates in a backscattering geometry resulting in a large solid angle of up to 1.1\u2005steradian. The detector, coupled with the Xspress\u20053 pulse processor, enables measurements at high count rates of up to 10\n                    <jats:sup>6<\/jats:sup>\n                    \u2005counts per second per sensor. The measured energy resolution of \u223c129\u2005eV (Mn\n                    <jats:italic>K<\/jats:italic>\n                    \u03b1 at 10000\u2005counts\u2005s\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) is only minimally impaired at the highest count rates. The resulting high detection sensitivity allows for an accurate determination of trace element distributions such as in thin frozen hydrated biological specimens. First proof-of-principle measurements using continuous-movement 2D scans of frozen hydrated HeLa cells as a model system are reported to demonstrate the potential of the new detection system.\n                  <\/jats:p>","DOI":"10.1107\/s1600577519014048","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T11:06:36Z","timestamp":1574852796000},"page":"60-66","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":24,"title":["X-ray fluorescence analysis of metal distributions in cryogenic biological samples using large-acceptance-angle SDD detection and continuous scanning at the Hard X-ray Micro\/Nano-Probe beamline P06 at PETRA III"],"prefix":"10.1107","volume":"27","author":[{"given":"C.","family":"Rumancev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gr\u00e4fenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"V\u00f6pel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Stuhr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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