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Naturally occurring crosslinks in collagen stabilize its intermolecular structure\n                    <jats:italic>in vivo<\/jats:italic>\n                    , whereas chemical treatments for introducing synthetic crosslinks are often carried out\n                    <jats:italic>ex vivo<\/jats:italic>\n                    to improve the physical properties or heat stability of the collagen fibres for applications in biomaterials or leather production. Effective protection of intrinsic natural crosslinks as well as allowing them to contribute to collagen stability together with synthetic crosslinks can reduce the need for chemical treatments. However, the contribution of these natural crosslinks to the heat stability of collagen fibres, especially in the presence of synthetic crosslinks, is as yet unknown. Using synchrotron small-angle X-ray scattering, the\n                    <jats:italic>in situ<\/jats:italic>\n                    role of natural and synthetic crosslinks on the stabilization of the intermolecular structure of collagen in skins\u00a0was studied. The results showed that, although natural crosslinks affected the denaturation temperature of collagen, they were largely weakened when crosslinked using chromium sulfate. The development of synergistic crosslinking chemistries could help retain the intrinsic chemical and physical properties of collagen-based biological materials.\n                  <\/jats:p>","DOI":"10.1107\/s1600577520009479","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T14:19:27Z","timestamp":1597846767000},"page":"1376-1381","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":6,"title":["<i>In situ<\/i>\n                    structural studies during denaturation of natural and synthetically crosslinked collagen using synchrotron SAXS"],"prefix":"10.1107","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-3036","authenticated-orcid":true,"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-5052","authenticated-orcid":true,"given":"Jenna","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2763-5922","authenticated-orcid":true,"given":"Rafea","family":"Naffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Mansel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9549-0625","authenticated-orcid":true,"given":"Catherine","family":"Maidment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9864-1150","authenticated-orcid":true,"given":"Geoff","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4371-9085","authenticated-orcid":true,"given":"Sujay","family":"Prabakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"ju5017_bb1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1136\/bjo.2009.164228","volume":"94","author":"Ashwin","year":"2010","journal-title":"Br. 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