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Fluorescence microscopy is one of the pivotal techniques that provides molecular specificity for imaging in real space, but is limited to labeled components. In contrast, X-rays are sensitive to electron density variations, enabling label-free structural characterization in reciprocal space. In particular, scanning small-angle X-ray scattering (SAXS) combines information from real and reciprocal space and enables access to intact cells owing to the high penetration power of X-rays. To harness the complementary strengths of these approaches, we developed a correlative imaging platform integrating a modular, compact, and beamline-compatible fluorescence microscope with scanning SAXS. The system enables fast sequential imaging of the same cellular regions under hydrated, near-native conditions using a dedicated microfluidic chamber. Applying this approach to keratin bundles in epithelial cells and force-generating actomyosin in cardiomyocytes, we demonstrate good agreement between fluorescence and SAXS-derived orientation maps. This result shows that label-free SAXS captures cytoskeletal organization throughout the cell, and can be directly linked to specific molecular information under physiologically relevant conditions. 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