{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:54:22Z","timestamp":1778860462265,"version":"3.51.4"},"reference-count":28,"publisher":"International Union of Crystallography (IUCr)","issue":"2","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr F Struct Biol Cryst Commun","Acta Cryst F","Acta Cryst Sect F","Acta Crystallogr F","Acta Crystallogr Sect F","Acta Cryst F Struct Biol Cryst Commun","Acta Cryst Sect F Struct Biol Cryst Commun"],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:p>Snake-venom L-amino-acid oxidases (SV-LAAOs) trigger a wide range of local and systematic effects, including inhibition of platelet aggregation, cytotoxicity, haemolysis, apoptosis and haemorrhage. These effects mainly arise from the uncontrolled release of the hydrogen peroxide that is produced by the redox reaction involving L-amino acids catalyzed by these flavoenzymes. Taking their clinical relevance into account, few SV-LAAOs have been structurally characterized and the structural determinants responsible for their broad direct and indirect pharmacological activities remain unclear. In this work, an LAAO from<jats:italic>Bothrops jararacussu<\/jats:italic>venom (BJu-LAAO) was purified and crystallized. The BJu-LAAO crystals belonged to space group<jats:italic>P<\/jats:italic>2<jats:sub>1<\/jats:sub>, with unit-cell parameters<jats:italic>a<\/jats:italic>\u00a0=\u00a066.38,<jats:italic>b<\/jats:italic>= 72.19,<jats:italic>c<\/jats:italic>= 101.53\u2005\u00c5, \u03b2 = 90.9\u00b0. The asymmetric unit contained two\u00a0molecules and the structure was determined and partially refined at 3.0\u2005\u00c5 resolution.<\/jats:p>","DOI":"10.1107\/s1744309111054923","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T02:58:33Z","timestamp":1327546713000},"page":"211-213","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":7,"title":["Crystallization and preliminary X-ray diffraction analysis of an<scp>L<\/scp>-amino-acid oxidase from<i>Bothrops jararacussu<\/i>venom"],"prefix":"10.1107","volume":"68","author":[{"given":"Anwar","family":"Ullah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Coronado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio T.","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Betzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raghuvir K.","family":"Arni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"key":"dp5017_bb1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cbpa.2008.07.007","volume":"151","author":"Alves","year":"2008","journal-title":"Comp. 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