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Herein, the crystal growth behaviors of amorphous anti-inflammatory drug nimesulide (NIME) are systemically investigated in the glassy and supercooled liquid state as a function of temperature. A sudden over-tenfold increase is observed in the bulk crystal growth of NIME on cooling below its glass transition temperature (<jats:italic>T<\/jats:italic>\n                  <jats:sub>g<\/jats:sub>). This fast growth behavior is known as a glass-to-crystal (GC) mode and has been reported in some molecular glasses. Fast surface crystal growth of NIME can persist up to <jats:italic>T<\/jats:italic>\n                  <jats:sub>g<\/jats:sub>\u2009+\u200957\u00b0C with a weak jump in its growth rates at 30\u201340\u00b0C. In addition, surface crystal growth and GC growth of NIME exhibit an almost identical temperature dependence, supporting the view that GC growth is indeed a surface-facilitated process. Moreover, the bubble-induced fast crystal growth of NIME is observed in the interior of its supercooled liquid with approximately the same growth kinetics as surface crystal growth. These findings are relevant for a full understanding of the surface-related crystallization behaviors and physical stability of amorphous pharmaceutical formulations.<\/jats:p>","DOI":"10.1107\/s2052520621012749","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T16:18:43Z","timestamp":1643300323000},"page":"33-39","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":9,"title":["Fast crystal growth of amorphous nimesulide: implication of surface effects"],"prefix":"10.1107","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-4722","authenticated-orcid":true,"given":"Qin","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chai-Yee","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"329","published-online":{"date-parts":[[2022,1,15]]},"reference":[{"key":"yv5001_bb1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s11095-009-0021-1","volume":"27","author":"Alonzo","year":"2010","journal-title":"Pharm. 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