{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:53:22Z","timestamp":1789826002051,"version":"4.0.1"},"reference-count":41,"publisher":"International Union of Crystallography (IUCr)","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"funder":[{"name":"Major Project of Natural Science Foundation in Colleges of Jiangsu Province","award":["24KJA350003"],"award-info":[{"award-number":["24KJA350003"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20211114"],"award-info":[{"award-number":["BK20211114"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical General Projects of Jiangsu Commission of Health","award":["H2023070"],"award-info":[{"award-number":["H2023070"]}]},{"name":"Basic Research Foundation of Yancheng City","award":["YCBK202220"],"award-info":[{"award-number":["YCBK202220"]}]}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr B Struct Sci Cryst Eng Mater","Acta Crystallogr B","Acta Crystallogr B Struct Sci","Acta Cryst B","Acta Cryst B Struct Sci Cryst Eng Mater","Acta Cryst Sect B","Acta Cryst Sect B Struct Sci Cryst Eng Mater","Acta Crystallogr Sect B","Acta Crystallogr Sect B Struct Sci Cryst Eng Mater","Acta Crystallogr Sect B Struct Sci"],"accepted":{"date-parts":[[2024,10,30]]},"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:p>\n                    Drug polymorphism attracts considerable interest within the pharmaceutical field. Herein, we investigate the impact of low-concentration poly(ethylene oxide) (PEO) on the crystal growth of carbamazepine (CBZ) polymorphs in the glassy state. The addition of 3%(\n                    <jats:italic>w<\/jats:italic>\n                    \/\n                    <jats:italic>w<\/jats:italic>\n                    ) PEO increases 5.3-fold the bulk crystal growth rates of CBZ form III and 36.7-fold of form IV at 40\u00b0C (\n                    <jats:italic>T<\/jats:italic>\n                    <jats:sub>g<\/jats:sub>\n                    \u221211\u00b0C). However, the same content of PEO exhibits a negligible effect on the bulk crystal growth of form I. In addition, the effects of PEO on the crystal growth of the CBZ polymorph at the free surface are also explored. In the presence of 3%(\n                    <jats:italic>w<\/jats:italic>\n                    \/\n                    <jats:italic>w<\/jats:italic>\n                    ) PEO, surface growth rates of forms III and IV of CBZ are accelerated by 4.7-fold and 3.1-fold, respectively. For comparison, the same content of PEO exhibits an unexpected inhibitory effect on the surface growth rates of form I. Molecular-dynamic simulations attribute these polymorph-dependent effects of PEO mainly to the polymer enrichment at the interface and different crystal surface polymer interactions. This study is relevant for understanding the crystallization of amorphous pharmaceutical solids containing polymorphic drugs.\n                  <\/jats:p>","DOI":"10.1107\/s2052520624010515","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T12:26:07Z","timestamp":1734611167000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":2,"title":["Selective acceleration and inhibition of crystal growth of glass carbamazepine by low-concentration poly(ethylene oxide):effects of drug polymorph"],"prefix":"10.1107","volume":"81","author":[{"given":"Chongchong","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7472-3832","authenticated-orcid":true,"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-4722","authenticated-orcid":true,"given":"Qin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"tq5021_bb21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s11095-022-03427-3","volume":"40","author":"Chen","year":"2023","journal-title":"Pharm. Res."},{"key":"tq5021_bb40","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.1021\/acs.jpcb.6b05658","volume":"120","author":"Chen","year":"2016","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb22","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1021\/cg2005503","volume":"11","author":"Gunn","year":"2011","journal-title":"Cryst. Growth Des."},{"key":"tq5021_bb37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.addr.2015.11.021","volume":"100","author":"H\u00e9doux","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"tq5021_bb38","doi-asserted-by":"crossref","first-page":"5746","DOI":"10.1021\/jp112074w","volume":"115","author":"H\u00e9doux","year":"2011","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb41","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1021\/acs.jpcb.6b11816","volume":"121","author":"Huang","year":"2017","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb25","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1021\/acs.jpcb.7b07319","volume":"121","author":"Huang","year":"2017","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.apsb.2015.07.003","volume":"5","author":"Kalepu","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"tq5021_bb28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/mp5005146","volume":"12","author":"Kothari","year":"2015","journal-title":"Mol. Pharm."},{"key":"tq5021_bb10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1107\/S1600576720014636","volume":"54","author":"Li","year":"2021","journal-title":"J. Appl. Cryst."},{"key":"tq5021_bb34","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1021\/ar100040r","volume":"43","author":"Lu","year":"2010","journal-title":"Acc. Chem. Res."},{"key":"tq5021_bb18","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1021\/acs.molpharmaceut.4c00315","volume":"21","author":"Luo","year":"2024","journal-title":"Mol. Pharm."},{"key":"tq5021_bb11","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1021\/jp0555955","volume":"110","author":"Mapes","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb27","doi-asserted-by":"crossref","first-page":"10334","DOI":"10.1021\/jp406418n","volume":"117","author":"Powell","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb17","doi-asserted-by":"crossref","first-page":"8203","DOI":"10.1021\/jp501301y","volume":"118","author":"Powell","year":"2014","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb16","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1021\/acs.jpcb.5b05389","volume":"119","author":"Powell","year":"2015","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/bioinformatics\/btt055","volume":"29","author":"Pronk","year":"2013","journal-title":"Bioinformatics"},{"key":"tq5021_bb12","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1021\/acs.cgd.6b00252","volume":"16","author":"Shi","year":"2016","journal-title":"Cryst. Growth Des."},{"key":"tq5021_bb5","doi-asserted-by":"crossref","first-page":"119925","DOI":"10.1016\/j.ijpharm.2020.119925","volume":"590","author":"Shi","year":"2020","journal-title":"Int. J. Pharm."},{"key":"tq5021_bb6","doi-asserted-by":"crossref","first-page":"122098","DOI":"10.1016\/j.ijpharm.2022.122098","volume":"625","author":"Shi","year":"2022","journal-title":"Int. J. Pharm."},{"key":"tq5021_bb14","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.3390\/molecules28072919","volume":"28","author":"Shi","year":"2023","journal-title":"Molecules"},{"key":"tq5021_bb13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1107\/S2052520621012749","volume":"78","author":"Shi","year":"2022","journal-title":"Acta Cryst. B"},{"key":"tq5021_bb32","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1021\/acs.molpharmaceut.7b00097","volume":"14","author":"Shi","year":"2017","journal-title":"Mol. Pharm."},{"key":"tq5021_bb29","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1021\/acs.molpharmaceut.7b00854","volume":"14","author":"Shi","year":"2017","journal-title":"Mol. Pharm."},{"key":"tq5021_bb9","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1021\/acs.chemrev.5b00744","volume":"116","author":"Sosso","year":"2016","journal-title":"Chem. Rev."},{"key":"tq5021_bb33","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1002\/jps.22251","volume":"99","author":"Sun","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"tq5021_bb15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1208\/s12248-012-9345-6","volume":"14","author":"Sun","year":"2012","journal-title":"AAPS J."},{"key":"tq5021_bb20","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1021\/jp7120577","volume":"112","author":"Sun","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"tq5021_bb19","doi-asserted-by":"crossref","first-page":"074506","DOI":"10.1063\/1.3200228","volume":"131","author":"Sun","year":"2009","journal-title":"J. Chem. Phys."},{"key":"tq5021_bb4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.addr.2016.03.006","volume":"101","author":"Taylor","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"tq5021_bb2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.drudis.2007.09.005","volume":"12","author":"Vasconcelos","year":"2007","journal-title":"Drug Discovery Today"},{"key":"tq5021_bb36","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"tq5021_bb7","doi-asserted-by":"crossref","first-page":"18335","DOI":"10.1021\/acs.iecr.0c03304","volume":"59","author":"Xu","year":"2020","journal-title":"Ind. Eng. Chem. Res."},{"key":"tq5021_bb3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0169-409X(01)00098-9","volume":"48","author":"Yu","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"tq5021_bb8","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1021\/ja0351544","volume":"125","author":"Yu","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"tq5021_bb24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2016.01.005","volume":"100","author":"Yu","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"tq5021_bb26","first-page":"100834","volume":"18","author":"Zhang","year":"2023","journal-title":"Asia. J. Pharm. Sci."},{"key":"tq5021_bb31","doi-asserted-by":"crossref","first-page":"4308","DOI":"10.1039\/D1BM00104C","volume":"9","author":"Zhang","year":"2021","journal-title":"Biomater. Sci."},{"key":"tq5021_bb30","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/acs.molpharmaceut.0c00220","volume":"17","author":"Zhang","year":"2020","journal-title":"Mol. Pharm."},{"key":"tq5021_bb39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1021\/acs.macromol.5b02294","volume":"49","author":"Zhang","year":"2016","journal-title":"Macromolecules"},{"key":"tq5021_bb23","doi-asserted-by":"crossref","first-page":"256103","DOI":"10.1103\/PhysRevLett.106.256103","volume":"106","author":"Zhu","year":"2011","journal-title":"Phys. Rev. Lett."}],"container-title":["Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials"],"original-title":[],"link":[{"URL":"https:\/\/journals.iucr.org\/b\/issues\/2025\/01\/00\/tq5021\/tq5021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.iucr.org\/b\/issues\/2025\/01\/00\/tq5021\/tq5021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:49:55Z","timestamp":1763038195000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.iucr.org\/paper?S2052520624010515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["S2052520624010515"],"URL":"https:\/\/doi.org\/10.1107\/s2052520624010515","relation":{},"ISSN":["2052-5206"],"issn-type":[{"value":"2052-5206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"assertion":[{"value":"Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials","order":0,"name":"journal","label":"Publication","explanation":{"URL":"https:\/\/journals.iucr.org\/b"},"group":{"name":"general","label":"General"}},{"value":"research papers","order":1,"name":"content_type","label":"Content type","explanation":{"URL":"https:\/\/journals.iucr.org\/b\/services\/notesforauthors.html"},"group":{"name":"general","label":"General"}},{"value":"Available","URL":"https:\/\/scripts.iucr.org\/cgi-bin\/citedin?tq5021","order":2,"name":"article_metrics","label":"Article metrics","group":{"name":"general","label":"General"}},{"value":"Yes","order":0,"name":"peer_reviewed","label":"Peer reviewed","group":{"name":"peer_review","label":"Peer review"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review process","group":{"name":"peer_review","label":"Peer review"}},{"value":"4 September 2024","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication history"}},{"value":"30 October 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication history"}},{"value":"16 December 2024","order":2,"name":"published_online","label":"Published online","group":{"name":"publication_history","label":"Publication history"}},{"value":"\u00a9 Chongchong Tian\n                      et al.","order":0,"name":"copyright","label":"Copyright","explanation":{"URL":"https:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},"group":{"name":"copyright_and_licensing","label":"Copyright and licencing"}},{"value":"IUCr licence to publish","order":1,"name":"license","label":"Licence","explanation":{"URL":"https:\/\/journals.iucr.org\/copyright\/licencetopublish.html"},"group":{"name":"copyright_and_licencing","label":"Copyright and licencing"}}]}}