{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:21:41Z","timestamp":1783531301474,"version":"3.55.0"},"reference-count":21,"publisher":"International Union of Crystallography (IUCr)","issue":"4","license":[{"start":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:00:00Z","timestamp":1426291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T00:00:00Z","timestamp":1426291200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Struct Chem","Acta Crystallogr C","Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst C Struct Chem","Acta Cryst Sect C","Acta Cryst Sect C Struct Chem","Acta Crystallogr Sect C","Acta Crystallogr Sect C Struct Chem","Acta Crystallogr Sect C Cryst Struct Commun"],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:p>Four new cocrystals of pyrimidin-2-amine and propane-1,3-dicarboxylic (glutaric) acid were crystallized from three different solvents (acetonitrile, methanol and a 50:50 wt% mixture of methanol and chloroform) and their crystal structures determined. Two of the cocrystals, namely pyrimidin-2-amine\u2013glutaric acid (1\/1), C<jats:sub>4<\/jats:sub>H<jats:sub>5<\/jats:sub>N<jats:sub>3<\/jats:sub>\u00b7C<jats:sub>6<\/jats:sub>H<jats:sub>8<\/jats:sub>O<jats:sub>4<\/jats:sub>, (I) and (II), are polymorphs. The glutaric acid molecule in (I) has a linear conformation, whereas it is twisted in (II). The pyrimidin-2-amine\u2013glutaric acid (2\/1) cocrystal, 2C<jats:sub>4<\/jats:sub>H<jats:sub>5<\/jats:sub>N<jats:sub>3<\/jats:sub>\u00b7C<jats:sub>6<\/jats:sub>H<jats:sub>8<\/jats:sub>O<jats:sub>4<\/jats:sub>, (III), contains glutaric acid in its linear form. Cocrystal\u2013salt bis(2-aminopyrimidinium) glutarate\u2013glutaric acid (1\/2), 2C<jats:sub>4<\/jats:sub>H<jats:sub>6<\/jats:sub>N<jats:sub>3<\/jats:sub><jats:sup>+<\/jats:sup>\u00b7C<jats:sub>6<\/jats:sub>H<jats:sub>6<\/jats:sub>O<jats:sub>4<\/jats:sub><jats:sup>2\u2212<\/jats:sup>\u00b72C<jats:sub>6<\/jats:sub>H<jats:sub>8<\/jats:sub>O<jats:sub>4<\/jats:sub>, (IV), was crystallized from the same solvent as cocrystal (II), supporting the idea of a cocrystal\u2013salt continuum when both the neutral and ionic forms are present in appreciable concentrations in solution. The diversity of the packing motifs in (I)\u2013(IV) is mainly caused by the conformational flexibility of glutaric acid, while the hydrogen-bond patterns show certain similarities in all four structures.<\/jats:p>","DOI":"10.1107\/s2053229615004283","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T12:44:14Z","timestamp":1426250654000},"page":"276-283","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":10,"title":["Three cocrystals and a cocrystal salt of pyrimidin-2-amine and glutaric acid"],"prefix":"10.1107","volume":"71","author":[{"given":"Isaac","family":"Odiase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine E.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruksanna","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry S.","family":"Yufit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon J.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2015,3,14]]},"reference":[{"key":"lg3157_bb1","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1039\/b402150a","author":"Almarsson","year":"2004","journal-title":"Chem. 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