{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:50:21Z","timestamp":1792666221054,"version":"4.5.0"},"reference-count":21,"publisher":"International Union of Crystallography (IUCr)","issue":"3","license":[{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html"},{"start":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T00:00:00Z","timestamp":1519776000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.iucr.org\/services\/copyrightpolicy.html#TDM"}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"short-container-title":["Acta Crystallogr C Struct Chem","Acta Crystallogr C","Acta Crystallogr C Cryst Struct Commun","Acta Cryst C","Acta Cryst C Struct Chem","Acta Cryst Sect C","Acta Cryst Sect C Struct Chem","Acta Crystallogr Sect C","Acta Crystallogr Sect C Struct Chem","Acta Crystallogr Sect C Cryst Struct Commun"],"published-print":{"date-parts":[[2018,3,1]]},"abstract":"<jats:p>\n                    Paracetamol [\n                    <jats:italic>N<\/jats:italic>\n                    -(4-hydroxyphenyl)acetamide, C\n                    <jats:sub>8<\/jats:sub>\n                    H\n                    <jats:sub>9<\/jats:sub>\n                    NO\n                    <jats:sub>2<\/jats:sub>\n                    ] has several polymorphs, just like many other drugs. The most stable polymorphs, denoted Forms I and II, can be obtained easily and their crystal structures are known. Crystals of the orthorhombic, less stable, room-temperature Form III are difficult to grow; they need a special recipe to crystallize and suffer from severe preferred orientation. A crystal structure model of Form III has been proposed and solved from a combination of structure prediction and powder X-ray diffraction (PXRD) [Perrin\n                    <jats:italic>et al.<\/jats:italic>\n                    (2009).\n                    <jats:italic>Chem. Commun.<\/jats:italic>\n                    <jats:bold>22<\/jats:bold>\n                    , 3181\u20133183]. The final\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>wp<\/jats:sub>\n                    value of 0.138 and the corresponding considerable residual trace were reasons to check its validity. A new structure determination of Form III using new high-resolution PXRD data led to a final\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>wp<\/jats:sub>\n                    value of 0.042 and an improvement of the earlier proposed model. In addition, a reversible phase transition was found at 170\u2013220\u2005K between the orthorhombic Form III and a novel monoclinic Form III-m. The crystal structure of Form III-m has been determined and refined from PXRD data to a final\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>wp<\/jats:sub>\n                    value of 0.059.\n                  <\/jats:p>","DOI":"10.1107\/s2053229618002619","type":"journal-article","created":{"date-parts":[[2018,2,27]],"date-time":"2018-02-27T11:53:52Z","timestamp":1519732432000},"page":"392-399","update-policy":"https:\/\/doi.org\/10.1107\/cm_01","source":"Crossref","is-referenced-by-count":15,"title":["Reassessment of paracetamol orthorhombic Form III and determination of a novel low-temperature monoclinic Form III-m from powder diffraction data"],"prefix":"10.1107","volume":"74","author":[{"given":"C\u00e9leste A.","family":"Reiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan B. van","family":"Mechelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-8161","authenticated-orcid":true,"given":"Kees","family":"Goubitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Peschar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"329","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"sk3670_bb1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.cossms.2009.06.004","volume":"13","author":"Bond","year":"2009","journal-title":"Curr. Opin. Solid State Mater. Sci."},{"key":"sk3670_bb2","unstructured":"Clissold, S. P. (1986). Drugs, 32, Suppl. 4, 46-59."},{"key":"sk3670_bb32","unstructured":"Degen, T., Sadki, M., Bron, E., K\u00f6nig, U. & N\u00e9nert, G. (2014). Powder Diffr. 29, Suppl. S2, S13-S18."},{"key":"sk3670_bb3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/BF01979491","volume":"48","author":"Di Martino","year":"1997","journal-title":"J. Therm. Anal."},{"key":"sk3670_bb4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-5173(95)04127-3","volume":"128","author":"Di Martino","year":"1996","journal-title":"Int. J. Pharm."},{"key":"sk3670_bb6","doi-asserted-by":"crossref","unstructured":"Druzhbin, D. A., Drebushchak, T. N., Min`kov, V. S. & Boldyreva, E. V. (2015). J. Struct. 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